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http://dx.doi.org/10.1021/cr078270o | DOI Listing |
Int J Mol Sci
December 2024
Institute of Technical Physics and Materials Science, HUN-REN Centre for Energy Research, Konkoly-Thege str. 29-33, H-1121 Budapest, Hungary.
We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were synthesized via wet chemical precipitation, followed by the addition of organic biominerals, such as magnesium gluconate and zinc gluconate, to enhance the bioactivity of the pure CP phase.
View Article and Find Full Text PDFPeerJ
January 2025
Department of Organismal Biology, Uppsala University, Uppsala, Sweden.
In this study, we attempt to illustrate fossil vertebrate dental tissue geochemistry and, by inference, its extent of diagenetic alteration, using quantitative, semi-quantitative and optical tools to evaluate bioapatite preservation. We present visual comparisons of elemental compositions in fish and plesiosaur dental remains ranging in age from Silurian to Cretaceous, based on a combination of micro-scale optical cathodoluminescence (CL) observations (optical images and scanning electron microscope) with minor, trace and rare earth element (REE) compositions (EDS, maps and REE profiles), as a tool for assessing diagenetic processes and biomineral preservation during fossilization of vertebrate dental apatite. Tissue-selective REE values have been obtained using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), indicating areas of potential REE enrichment, combined with cathodoluminescence (CL) analysis.
View Article and Find Full Text PDFbioRxiv
November 2024
Preventive and Restorative Dent. Sci., San Francisco, CA.
In this study, we performed synchrotron-based micro-X-ray fluorescence (μ-XRF) imaging of elements Zn and S, and X-ray absorption near edge spectroscopy (XANES) coupled with μ-XRF for identification of Zn and S species in the condylar zones of a rat temporomandibular joint (TMJ). Histologic localization of Zn and hypoxia-inducible factor-1α (HIF-1α) were mapped using an optical microscope. These data were visually correlated with μ-XRF and XANES data to provide insights into plausible biological S-species in Z-enriched condylar zones of a rat TMJ.
View Article and Find Full Text PDFInt J Nanomedicine
November 2024
Department of Traumatic Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China.
Background: Delayed healing and non-healing of bone defects pose significant challenges in clinical practice, with metal materials increasingly recognized for their significance in addressing these issues. Among these materials, Strontium (Sr) and Zinc (Zn) have emerged as promising agents for promoting bone repair. Building upon this insight, this research evaluates the impact of a porous Sr@Zn@SiO nanocomposite implant on bone regeneration, aiming to advance the field of bone repair.
View Article and Find Full Text PDFActa Biomater
January 2025
Department of Stratigraphy and Paleontology, Faculty of Sciences, University of Granada, Spain; Andalusian Earth Sciences Institute, CSIC-University of Granada, Armilla, Spain.
The mechanism of nacre formation in gastropods involves a vesicular system that transports organic and mineral precursors from the mantle epithelium to the mineralization chamber. Between them lies the surface membrane, a thick organic structure that covers the mineralization chamber and the forming nacre. The surface membrane is a dynamic structure that grows by the addition of vesicles on the outer side and recedes by the formation of interlamellar membranes on the inner side.
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