AI Article Synopsis
- This study aimed to explore the relationship between flow-mediated vasodilation (FMD) and plasma lipids/lipoproteins in the context of endothelial dysfunction and atherosclerosis.
- FMD measurements in 40 healthy volunteers revealed an inverse correlation between FMD responses and levels of plasma triglycerides, total cholesterol/HDL, and apolipoprotein B, suggesting that higher triglyceride levels could exacerbate endothelial dysfunction.
- The study also found variability in FMD measurements, with a standard deviation of 4.0% between different operators and 2.9% within the same subject across two measurements taken 4 weeks apart.
Article Abstract
Objective: Endothelial dysfunction is a critical, prerequisite step in atherosclerosis, and may be evaluated by flow-mediated vasodilatation (FMD). The objective of this study was to examine interrelationships between FMD and plasma lipids and lipoproteins, and to determine the between-operator and within-subject variability associated with this technique.
Material And Methods: FMD, plasma lipids and lipoproteins, including small dense LDL (sdLDL), were measured twice in 40 healthy volunteers, 4 weeks apart. Interrelationships between mean FMD responses and plasma lipids and lipoproteins were examined by correlation analysis. FMD measurements were taken by two independent operators, allowing determination of between-operator variability. Within-subject variability was determined by obtaining two measurements, 4 weeks apart, in every subject, and carried out by the same operator.
Results: FMD was inversely related to plasma triglycerides (r = -0.47, p = 0.002), total cholesterol/HDL cholesterol (r = -0.35, p = 0.03) and apolipoprotein B (r = -0.36, p = 0.02), but not to other plasma lipids and lipoproteins. When measuring variation in FMD, the following results were found: Between operators (SD = 4.0 FMD%) and within subjects (SD = 2.9 FMD%).
Conclusions: The associations between FMD, plasma triglycerides and apoB provide evidence supporting a role for triglyceride-rich lipoproteins in endothelial dysfunction.
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| http://dx.doi.org/10.1080/00365510802460474 | DOI Listing |
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