This autobiographical article recounts a 60-year career on research and teaching, 40 of which focused on interpersonal violence against other family members. Much of that research was carried despite prevailing beliefs which characterized either the methodology or the theory to be wrong. The article illustrates four underlining themes: iconoclasm; capitalizing on chance occurrences to select research topics; the conflict between ideology, evidence, and steps taken by critics to deny or discredit the results of my research; and the role of the personal history and the personality of the researcher in molding a scientific career.
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http://dx.doi.org/10.1177/1524838008323795 | DOI Listing |
J Exp Biol
August 2010
Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33149, USA.
Marine teleosts generally secrete basic equivalents (HCO(3)(-)) and take up Na(+) and Cl(-) in the intestine so as to promote absorption of H(2)O. However, neither the integration of these functions with feeding nor the potential role of the gut in ionoregulation and acid-base balance in freshwater have been well studied. The euryhaline killifish (Fundulus heteroclitus) is unusual in lacking both an acid-secreting stomach and a mechanism for Cl(-) uptake at the gills in freshwater.
View Article and Find Full Text PDFComp Biochem Physiol A Mol Integr Physiol
May 2010
Department of Biology, McMaster University, Hamilton, Ontario, Canada.
The effect in freshwater rainbow trout of digesting a commercial pellet meal on the renal handling of water, ions and acid-base equivalents was investigated through urine collection over a 48 h period following meal ingestion. The glomerular filtration rate (GFR) and urine flow rate (UFR) were reduced in fed fish between 12 and 24h following the meal, likely reflecting a loss of endogenous water across the gastric epithelium as a result of ingesting dry, ion-rich food pellets. The kidney was also responsible for the excretion of some excess dietary Ca(2+), and, to a much lesser extent, Na(+) and Cl(-), while the urinary excretion of K(+) was unaffected.
View Article and Find Full Text PDFJ Exp Biol
July 2009
McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.
The consequences of feeding and digestion on acid-base balance and regulation in a marine teleost (seawater-acclimated steelhead trout; Oncorhynchus mykiss) were investigated by tracking changes in blood pH and [HCO3-], as well as alterations in net acid or base excretion to the water following feeding. Additionally the role of the intestine in the regulation of acid-base balance during feeding was investigated with an in vitro gut sac technique. Feeding did not affect plasma glucose or urea concentrations, however, total plasma ammonia rose during feeding, peaking between 3 and 24 h following the ingestion of a meal, three-fold above resting control values (approximately 300 micromol ml(-1)).
View Article and Find Full Text PDFTrauma Violence Abuse
October 2008
Family Research Laboratory, University of New Hampshire, Durham, NH 03824.
J Exp Biol
August 2008
McMaster University, 1280 Main St. West, Hamilton, Ontario, Canada, L8S 4K1.
We investigated the potential acid-base and nitrogenous waste excretion challenges created by voluntary feeding in freshwater rainbow trout, with particular focus on the possible occurrence of an alkaline tide (a metabolic alkalosis created by gastric HCl secretion during digestion). Plasma metabolites (glucose, urea and ammonia) were measured at various time points before and after voluntary feeding to satiation (approximately 5% body mass meal of dry commercial pellets), as was the net flux of ammonia and titratable alkalinity to the water from unfed and fed fish. Arterial blood, sampled by indwelling catheter, was examined for post-prandial effects on pH, plasma bicarbonate and plasma CO2 tension.
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