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[A case of bromadiolone poisoning leading to digestive tract, abdominal hemorrhage and secondary paralytic ileus].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
September 2022
Emergency Department of Banan District People's Hospital of Chongqing, Chongqing 401320, China.
Bromadiolone, commonly known as super warfarin, is a long-acting coumarin dicoumarin rodenticide. The mechanism of bromadiolone is mainly to inhibit vitamin K1 epoxide reductase and affect the synthesis of coagulation factors Ⅱ, Ⅶ, Ⅸ and Ⅹ, which causes blood coagulation dysfunction and systemic multiple organ hemorrhage. Here, we report of a case of bromadiolone poisoning patient who had digestive tract, abdominal hemorrhage, as well as secondary paralytic ileus.
View Article and Find Full Text PDFSimultaneous Determination of 13 Anticoagulant Rodenticidesin Human Blood by Liquid Chromatography-Tandem Mass Spectrometry and its Application in Three Poisoning Cases.
J Forensic Sci
May 2018
Department of Forensic Toxicology, Institute of Forensic Science, Ministry of Justice, Shanghai Key Laboratory of Forensic Medicine, No. 1347, West Guangfu Road, Shanghai, 200063, China.
Anticoagulant rodenticides are widely used for rodent control around the world. A rapid and sensitive method was developed and validated for the simultaneous determination of 13 anticoagulant rodenticides (coumafuryl, pindone, valone, warfarin, coumatetralyl, coumachlor, diphacinone, dicumarol, chlorophacinone, bromadiolone, difenacoum, flocoumafen, and brodifacoum) in human blood by liquid chromatography-tandem mass spectrometry. After liquid-liquid extraction, the anticoagulant rodenticides were separated on an Eclipse Plus C18 column.
View Article and Find Full Text PDFOn the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo.
Neurotox Res
July 2017
Molecular & Clinical Pharmacology, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, 70000, Santiago 7, Chile.
Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted by DT-diaphorase to nontoxic leukoaminochrome. However, when administered exogenously into rat striatum, aminochrome is able to produce damage to dopaminergic neurons. Because of a recent report that substantia nigra pars compacta (SNpc) tyrosine hydroxylase (T-OH) levels were unaltered by aminochrome when there was cell shrinkage of dopaminergic neurons along with a reduction in striatal dopamine release, the following study was conducted to more accurately determine the role of DT-diaphorase in aminochrome neurotoxicity.
View Article and Find Full Text PDFThe history of the discovery and development of vitamin K and its antagonists, the oral anticoagulants dicoumarol and warfarin, are fascinating, triumphant landmarks in the annals of medicine. Vitamin K was found by Carl Peter Henrik Dam and Fritz Schønheyder from the University of Copenhagen. The discovery was initiated by Dam, by a lucky choice of chicks in the dissertation of sterol metabolism, since the vitamin is not formed by intestinal bacteria in these animals.
View Article and Find Full Text PDFDicoumarol toxicity in neonatal calves associated with the feeding of sweet vernal (Anthoxanthum odoratum) hay.
Aust Vet J
June 2003
Smithton Veterinary Service, PO Box 23, Smithton, Tasmania, 7330.
Neonatal calves from a seasonal dairy herd in North Western Tasmania were presented for veterinary care due to mortalities and bleeding from multiple orifices. Necropsy examination revealed free blood throughout the parenchymatous organs, body cavities and connective tissues. There was no history of anticoagulant exposure, however, high quantities of dicoumarol were found in samples from hay fed to recently calved cows.
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