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Point-of-Care Testing to Combat Congenital Syphilis-The Time Is Now.
JAMA
January 2025
Department of Obstetrics, Gynecology & Reproductive Sciences, UTHealth Houston, Houston, Texas.
[Translated article] AEDV Expert Consensus for the Management of Syphilis.
Actas Dermosifiliogr
October 2024
Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, España; Grupo investigación en ITS y VIH de la AEDV.
Article Synopsis
- Syphilis cases are on the rise in Western countries, with Spain reporting 6,613 new cases in 2021, predominantly affecting men, and showing an increasing trend since 2000.
- The clinical presentation of syphilis varies widely, with typical lesions like chancres and syphilitic roseola, as well as other atypical manifestations that can complicate diagnosis.
- Modern diagnostic methods include molecular assays and automated treponemal tests, with treatment primarily involving penicillin, especially recommended for pregnant women and individuals with HIV; follow-up testing is crucial for ensuring effective treatment and monitoring for reinfection.
Article Synopsis
- * A notable rise in syphilis cases has been observed among women in their 20s, increasing over three times, while the number of pregnant women with the disease also rose at the end of 2022.
- * While congenital syphilis rates have remained stable due to effective early detection during pregnancy, the rising trend among young women poses a risk for future outbreaks, highlighting the need for targeted public health education and testing strategies.
Southern African HIV Clinicians Society Guideline for the clinical management of syphilis.
South Afr J HIV Med
April 2024
Southern African HIV Clinicians Society (SAHCS), Johannesburg, South Africa.
Syphilis, 'the great imitator', caused by infection, remains a complex and multifaceted disease with a rich history of clinical diversity. This guideline aims to be a comprehensive guide for healthcare workers in Southern Africa, offering practical insights into the epidemiology, pathogenesis, clinical manifestations, diagnostic testing, therapeutic principles, and public health responses to syphilis. Although the syphilis burden has declined over the years, recent data indicate a troubling resurgence, particularly among pregnant women and neonates.
View Article and Find Full Text PDFCongenital syphilis: the re-emergence of a forgotten disease.
BMJ Case Rep
January 2024
Neonatology, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.
A preterm newborn presented at birth with generalised oedema, disseminated bullous and desquamative exanthema with palmoplantar involvement and hepatomegaly, admitted to the neonatal intensive care unit with severe multisystemic disease, haemodynamic instability and respiratory distress. The mother had a history of treated latent syphilis before pregnancy. Venereal Disease Research Laboratory screening was negative in the first trimester, titre 1:2 in second trimester and 1:32 in the third trimester, a result only available to the medical team at birth.
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