Goals Of Work: Quality of life (QOL) is significantly impaired in patients with acute myeloid leukemia (AML), and fatigue is the most common and disabling symptom; effective treatment measures have yet to be found. Cytokines, biomarkers of inflammation, may moderate both health outcomes, but published data are limited. We looked at the role of cytokines in modulating QOL and fatigue in an older AML population.
Patients And Methods: We recruited 34 English-speaking patients (23 men, 11 women) aged 50 or older with AML within 1 year of diagnosis. QOL and fatigue were assessed with validated questionnaires. Blood was simultaneously drawn for quantitative measurement of a 13-cytokine panel. Repeat measurements were done 4-6 weeks later (n = 28 patients). Spearman correlations between health measures and cytokine levels were examined at baseline, as were changes in variables between time points. A potentially clinically important correlation was defined as an r > or = 0.30.
Results: At baseline, potentially clinically important correlations were noted between global QOL and interferon (IFN)-gamma (r = -0.376, p = 0.031), interleukin (IL)-2 (r = -0.340, p = 0.053), IL-5 (r = -0.368, p = 0.035), IL-8 (r = -0.312, p = 0.077), and TNF-alpha (r = -0.326, p = 0.064). A similar correlation was observed between IL-6 and fatigue (r = 0.332, p = 0.059). Between time points, there were no potentially important correlations between changes in global QOL and any cytokine. However, potentially important correlations with fatigue were seen with both IL-5 (r = 0.344, p = 0.073) and IL-10 (r = 0.326, p = 0.091) between time points.
Conclusions: These preliminary data provide support for a larger controlled study of cytokines, fatigue, and QOL in patients with AML.
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http://dx.doi.org/10.1007/s00520-008-0512-3 | DOI Listing |
J Epidemiol Popul Health
February 2025
CEReSS-Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France.
Biotechniques
January 2025
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
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December 2024
Medicine, Universidad Santiago de Cali, Cali, COL.
Ventricular tachycardia (VT) is a life-threatening arrhythmia often leading to sudden cardiac death, particularly in critically ill patients. Refractory VT, characterized by recurrent episodes requiring intervention, poses unique challenges for management, necessitating advanced diagnostic and therapeutic strategies. This systematic review evaluates the impact of imaging and pharmacological treatments in managing refractory VT in critically ill patients.
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December 2024
Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine, Pharmacy and Dentistry of Fez, Sidi Mohamed Ben Abdellah University, Fez, MAR.
Background Urinary incontinence is a significant health problem with physical, social, economic, and psychological consequences for patients and their quality of life. The aim of our study is to determine the impact of urinary incontinence on the quality of life and to identify its determinants in patients with this condition. Materials and methods A cross-sectional study was carried out in the diagnostic center of Centre Hospitalier Universitaire (CHU) Hassan II in Fez, Morocco, between June and September 2019.
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December 2024
Department of Biological Science and Nursing, Yokohama City University Graduate School of Medicine, Yokohama, JPN.
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