We report a case of sclerosing angiomatoid nodular transformation of the spleen incidently discovered in a 41-year-old man. The macroscopic examination showed the presence of a reddish brown, well delineated but not encapsulated, multinodular lesion being histologically characterized by nodules made up of complex vascular structures lined by monomorphous but non atypical endothelial cells, surrounded by fibrin and a collagen stroma rich in spumous macrophages and hemosiderophages. The immunohistochemical markers carried out showed the presence of capillaries, veins and sinusoids normally found within the splenic parenchyma, but adopting an unusual configuration. This distinct entity, recently described and completely benign, must be included in the differential diagnosis of the vascular lesions of the spleen, which includes, among others, the hemangioma, the littoral cell angioma, the hemangioendothelioma and the inflammatory myofibroblastic tumor.
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