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In our study, four species of wood-decaying fungi with perennial fruiting bodies were used as the source of biologically active compounds (BACs) - Inonotus obliquus (chaga), Fomitopsis pinicola, Fomes fomentarius, and Ganoderma applanatum. Fungi have a wide range of secondary metabolites but are used much less frequently than plants in both folk and official medicine. Fungotherapy could be considered a promising trend in the development of modern natural therapy.
View Article and Find Full Text PDFRole of MMP-2 and MMP-9 in the Relationship between Inflammation, Fibrosis, and Apoptosis during Progression of Non-Alcoholic Fatty Liver Disease and Diagnostic Significance of Plasma Levels of Their Active Forms.
Biochemistry (Mosc)
November 2024
Zilber Medical Institute, Petrozavodsk State University, Petrozavodsk, Karelia, 185910, Russia.
MMP-2 and MMP-9 play an important role in pathogenesis of chronic liver diseases, participating in the processes of inflammation and fibrosis. Their role in progression of non-alcoholic fatty liver disease (NAFLD) is poorly understood. Analysis of MMP-2, -9 levels in the blood plasma of patients with different forms of NAFLD [liver steatosis (LS) and non-alcoholic steatohepatitis (NASH) of weak (-WA), moderate (MA), high (-HA) activity without pronounced fibrosis] was performed.
View Article and Find Full Text PDFBehavioral Features and Blood Enzyme Activity in Offspring of Rats Conceived from an Alcohol-Intoxicated Father.
Biochemistry (Mosc)
November 2024
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russia.
Article Synopsis
- * Results show that offspring of intoxicated fathers have significantly reduced motor activity and altered anxiety-like and depressive-like behaviors.
- * The findings suggest that alcohol consumption by males may affect gene methylation in offspring, leading to changes in enzyme activity and neuropeptide balance that influence behavior.
Neuroimmune Characteristics of Animals with Prenatal Alcohol Intoxication.
Biochemistry (Mosc)
November 2024
Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, 119002, Russia.
Neuroinflammation can be an important factor of many disorders in central nervous system (CNS) including cognitive dysfunction, affective disorders, and addictive behavior associated with prenatal alcohol exposure and presented in early adulthood. In this study we used an experimental rodent model of prenatal alcohol (PA) exposure (consumption of a 10% ethanol solution by female Wistar rats throughout pregnancy), multiplex immunofluorescence analysis of interleukins (IL-1α, IL-1β, IL-3, IL-6, IL-9, and IL-12), tumor necrosis factor (TNF-α), and chemokine CCL5, as well as quantitative real-time PCR to assess the level of cytokine mRNAs in the prefrontal cortex of the sexually mature (PND60) offspring - male and female rats with prenatal alcohol intoxication and control animals. Significant decrease in the content of TNF-α and interleukins IL-1β, IL-3, IL-6, IL-9 was detected in the prefrontal cortex of male, but not in the female PA offspring.
View Article and Find Full Text PDFAssociation of Peripheral Markers of Oxidative Stress with Clinical Parameters and Inflammatory Factors in Alcoholic Patients.
Biochemistry (Mosc)
November 2024
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634014, Russia.
One of the fundamental problems in studying addiction is elucidation of mechanisms of alcohol dependence (AD) development. Disturbances of cellular redox balance and inflammation play an important role in AD pathogenesis. Deciphering associations between biological and clinical indicators can elucidate molecular mechanisms of disease pathogenesis.
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