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Filename: controllers/Detail.php
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Aim: To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas.
Methods: Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical charts and histopathology reports. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1. Quantification was based on the intensity and distribution of nuclear staining.
Results: Univariate analysis showed that sex (P=0.019) and capsular invasion (P=0.010) were significant predictors of lymph node metastases, whereas age (P=0.96), histopathological variant (P=0.075), size (P=0.556) and multifocality (P=0.131) were not. Univariate analysis also showed that overexpression of cyclin D1 (P<0.001) and underexpression of p27 (P<0.001) predicted lymph node metastases in papillary thyroid carcinomas. There was a significant correlation between cyclin D1 (P=0.024) and p27 (P=0.029) expression in two prognostic groups of low and high risk. Low risk group was cyclin D1 negative and p27 positive, while high risk group was cyclin D1 positive and p27 negative. Multivariate analysis confirmed that sex (P=0.041), capsular invasion (P=0.027), and p27 (P<0.001) were strong independent predictors of lymph node metastases in the high-risk group.
Conclusions: Immunohistochemical analysis of p27 expression may be a valuable tool for identifying risk of lymph node metastases and more aggressive behavior of papillary thyroid carcinoma.
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http://dx.doi.org/10.3325/cmj.2008.5.643 | DOI Listing |
PLoS One
December 2024
Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
Gingival overgrowth caused by cyclosporine A is due to increased fibroblast proliferation in gingival tissues. Cell cycle system balances proliferation and anti-proliferation of gingival fibroblasts and plays a role in the maintenance of its population in gingival tissues. When cells detect and respond to abnormalities (e.
View Article and Find Full Text PDFInt J Hematol Oncol Stem Cell Res
October 2024
Department of Haematology and Blood Transfusion, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
Up-regulation of the microRNA-625 and abnormal expression of the Sox2 gene have been studied and seen in several tumors. Few reports have also shown the aberrant expression of miR-625 and Sox2 expression in various cancers. Several studies have also confirmed that phosphatidylinositol 3' -kinase /protein kinase B pathways regulate hematological malignancies, including Acute Myeloid Leukemia (AML).
View Article and Find Full Text PDFJ Dairy Sci
December 2024
Dairy Nutrition and Function, Key Laboratory of Sichuan Province, New Hope Dairy Co., Ltd., Chengdu, Sichuan, 610023, China; Chengdu Molecular Power Biotechnology Co., Ltd., Chengdu, Sichuan, 611732; China.
Sarcopenia is an age-related muscle loss, fiber number and decreased regenerative capacity with increased abundance of ROS levels and electron transport chain (ETC) abnormalities. The aim of the study is to investigate the anti-sarcopenia effect of MFG-E8 in alleviating skeletal muscle dysfunction induced by D-gal, reveal the mechanism on promoting myoblast cell proliferation and mediating cell cycle. In vivo experiment showed that MFG-E8 can improve the anti-oxidant status and increase soleus muscle mass (35.
View Article and Find Full Text PDFHistol Histopathol
November 2024
Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, PR China.
Objective: Accumulating evidence has implicated matrix metalloproteinases (MMPs) in the progression of human cancers. Matrix metallopeptidase 25 (MMP25) is a membrane-type MMP whose role in tumorigenesis and cancer development is not well understood. Here, we investigated the functions of MMP25 in tongue squamous cell carcinoma (TSCC).
View Article and Find Full Text PDFCell Commun Signal
December 2024
Institute of Human Genetics, Jena University Hospital, Am Klinikum 1, 07740, Jena, Germany.
Background: Prostate cancer (PCa) is a public health problem mostly reported in developed countries. The androgen receptor (AR) regulates the development and physiological function of normal prostate as well as the proliferation of cancerous prostate tissue. Treatment with supraphysiological androgen levels (SAL) is used in bipolar androgen therapy and inhibits PCa growth, suggesting SAL induces a tumor suppressive program.
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