Aim Of The Study: To estimate concentration of fetuin A in children with nephrotic syndrome (NS).
Material And Methods: 53 children with NS aged from 2.5 to 17.2 years (mean age 7.7 +/- 4.4 years), 27 in remission of NS, 26 in relapse of NS were involved into the study. The control group consisted of 22 healthy children, aged from 6.5 to 17.5 years, mean age 10.8 +/- 3.3 years. In all children serum concentration of fetuin A, calcium, phosphorus, total cholesterol, albumin, triglycerides, and total daily urine protein loss were measured.
Results: The concentration of fetuin A in children in relapse was significantly lower compared to children in remission and control group (65.9 +/- 28; 87.2 +/- 23.2; 101.9 +/- 11.6 ng/mL, respectively, p < 0.0001). Significant correlation was found between concentrations of fetuin A and albumin level (r = 0.36, p < 0.05) and calcium concentration (r = 0.30, p < 0.05) and negative correlation between concentration of fetuin A and daily proteinuria (r = -0.36, p < 0.05).
Conclusion: Low concentration of fetuin A in children in relapse of NS it may depends on proteinuria.
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