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Efficacy of Army Combat Fitness Test 12-Week Exercise Program Among Females.
Mil Med
January 2025
University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Introduction: The dearth of research investigating the efficacy of virtual Army Combat Fitness Test (ACFT) training programs among female populations necessitates further exploration. This study aims to evaluate the effectiveness of a 12-week ACFT virtual exercise program among female participants.
Materials And Methods: Nine female participants (age = 19.
A Novel Hybrid Improved RIME Algorithm for Global Optimization Problems.
Biomimetics (Basel)
December 2024
Department of Computer Science, Durham University, Durham DH1 3LE, UK.
The RIME algorithm is a novel physical-based meta-heuristic algorithm with a strong ability to solve global optimization problems and address challenges in engineering applications. It implements exploration and exploitation behaviors by constructing a rime-ice growth process. However, RIME comes with a couple of disadvantages: a limited exploratory capability, slow convergence, and inherent asymmetry between exploration and exploitation.
View Article and Find Full Text PDFEarly life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter.
Drug Alcohol Depend
January 2025
Department of Internal Medicine, College of Medicine, Charles R. Drew University of Medicine and Science, 1731 E. 120th St, Los Angeles, CA 90059, USA. Electronic address:
Background: Early life stress (ELS) increases the risk of substance use disorder (SUD) in adulthood. The pathway from ELS to SUD is hypothesized to be influenced by sex. We examine the impact of ELS on adolescent first substance use, a common precursor to adult SUDs, and test for sex differences in the relationship between ELS and risk of first use of alcohol, nicotine, and marijuana.
View Article and Find Full Text PDFCalciumZero: a toolbox for fluorescence calcium imaging on iPSC derived brain organoids.
Brain Inform
January 2025
Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA.
Calcium plays an important role in regulating various neuronal activities in human brains. Investigating the dynamics of the calcium level in neurons is essential not just for understanding the pathophysiology of neuropsychiatric disorders but also as a quantitative gauge to evaluate the influence of drugs on neuron activities. Accessing human brain tissue to study neuron activities has historically been challenging due to ethical concerns.
View Article and Find Full Text PDFEnhanced nano-LC-MS for analyzing dansylated oral cancer tissue metabolome dissolved in solvents with high elution strength.
Anal Chim Acta
February 2025
Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan, 333, Taiwan; Clinical Proteomics Core Laboratory, LinKou Chang Gung Memorial Hospital, Taoyuan, 333423, Taiwan. Electronic address:
Background: Tissue metabolomics analysis, alongside genomics and proteomics, offers crucial insights into the regulatory mechanisms of tumorigenesis. To enhance metabolite detection sensitivity, chemical isotope labeling (CIL) techniques, such as dansylation, have been developed to improve metabolite separation and ionization in mass spectrometry (MS). However, the dissolution of hydrophobic derivatized metabolites in solvents with high acetonitrile content limits the use of liquid chromatography (LC) systems with small-volume reversed-phase (RP) columns.
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