The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H(3) antagonists is described. The new compounds are high affinity histamine H(3) ligands that penetrate the CNS and occupy the histamine H(3) receptor in rat brain.
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| http://dx.doi.org/10.1016/j.bmcl.2008.09.077 | DOI Listing |
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