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Biliverdinuria Caused by Exonic Deletions in Two Dogs with Green Urine.
Genes (Basel)
November 2024
Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zürich, 8057 Zürich, Switzerland.
In heme degradation, biliverdin reductase catalyzes the conversion of biliverdin to bilirubin. Defects in the biliverdin reductase A gene () causing biliverdinuria are extraordinarily rare in humans, and this inborn error of metabolism has not been reported in other mammals. The objective of this study was to diagnose biliverdinuria and identify the causal variants in two adult mixed-breed dogs with life-long green urine.
View Article and Find Full Text PDFIn vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis.
Biomed Pharmacother
December 2023
Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA. Electronic address:
Article Synopsis
- Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder that often results in severe pulmonary fibrosis (HPSPF), with ongoing research for effective treatments.
- S-MRI-1867, a promising drug that targets cannabinoid receptors and inducible nitric oxide synthase, displays favorable properties such as moderate bioavailability and good metabolic stability in various animal models.
- A developed physiologically-based pharmacokinetic (PBPK) model accurately predicted the drug’s behavior in humans, supporting its potential for treating HPSPF.
Epiphyseal cartilage canal architecture and extracellular matrix remodeling in mucopolysaccharidosis VII dogs at the onset of postnatal growth.
Connect Tissue Res
November 2021
Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mucopolysaccharidosis (MPS) VII is a genetic, lysosomal storage disease characterized by abnormal accumulation of glycosaminoglycans in cells and tissues. MPS VII patients exhibit multiple failures of endochondral ossification during postnatal growth, including markedly delayed cartilage-to-bone conversion in the vertebrae and long bones. Cartilage canals provide the template for vascularization at the onset of secondary ossification.
View Article and Find Full Text PDFEpigenetic conversion of adult dog skin fibroblasts into insulin-secreting cells.
Vet J
May 2016
Department of Health, Animal Science and Food Safety, Università Degli Studi Di Milano, Via Celoria 10, 20133 Milano, Italy. Electronic address:
Diabetes is among the most frequently diagnosed endocrine disorder in dogs and its prevalence continues to increase. Medical management of this pathology is lifelong and challenging because of the numerous serious complications. A therapy based on the use of autologous viable insulin-producing cells to replace the lost β cell mass would be very advantageous.
View Article and Find Full Text PDFDelayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs.
Mol Genet Metab
November 2015
Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient β-glucuronidase activity, which leads to the accumulation of incompletely degraded glycosaminoglycans (GAGs). MPS VII patients present with severe skeletal abnormalities, which are particularly prevalent in the spine. Incomplete cartilage-to-bone conversion in MPS VII vertebrae during postnatal development is associated with progressive spinal deformity and spinal cord compression.
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