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Association between metabolic score for visceral fat index and BMI-adjusted skeletal muscle mass index in American adults.
Lipids Health Dis
January 2025
Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University, Changsha, 410003, People's Republic of China.
Background: The metabolic score for visceral fat (METS-VF) is a recently identified index for evaluating visceral fat, also referred to as abdominal obesity. The skeletal muscle mass index (SMI) serves as a critical measure for assessing muscle mass and sarcopenia. Both obesity and the reduction of muscle mass can significantly affect human health.
View Article and Find Full Text PDFLeptin drives glucose metabolism to promote cardiac protection via OPA1-mediated HDAC5 translocation and Glut4 transcription.
Funct Integr Genomics
January 2025
Department of Cardiology, Guizhou Provincial People`s Hospital, 83 Zhongshan East Road, Guiyang City, 550002, Guizhou Province, China.
Metabolic reprogramming, the shifting from fatty acid oxidation to glucose utilization, improves cardiac function as heart failure (HF) progresses. Leptin plays an essential role in regulating glucose metabolism. However, the crosstalk between leptin and metabolic reprogramming is poorly understood.
View Article and Find Full Text PDFIntrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies.
Sci Rep
January 2025
Instituto do Coração (InCor), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Doxorubicin-induced cardiomyopathy (DOX-IC) is a significant and common complication in patients undergoing chemotherapy, leading to cardiac remodeling and reduced heart function. We hypothesized that the intrapericardial injection of hydrogels derived from the cardiac decellularized extracellular matrix (dECM) loaded with adipose tissue-derived stromal cells (ASC) and their secretome dampens or reverses the progression of DOX-IC. DOX-IC was induced in Wistar male rats through ten weekly intra-peritoneal injections of doxorubicin (cumulative dose: 18 mg/kg).
View Article and Find Full Text PDFDisplacement MMG-based estimation of dynamic muscle viscoelasticity in the quadriceps during passive pedaling.
Sci Rep
January 2025
Graduate School of Interdisciplinary Science and Engineering of Health Systems, Okayama University, Okayama, 700-0082, Japan.
We explore the correlation between muscle viscoelasticity and displacement mechanomyography (DMMG) during passive joint movement. Current methods for assessing muscle viscoelasticity (which is essential for rehabilitation and sports conditioning) are limited in terms of simplicity, objectivity, and portability. We introduce a novel methodology employing DMMG during passive pedaling to evaluate these properties.
View Article and Find Full Text PDFAnisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo.
Nat Commun
January 2025
Department of Biomedical Engineering, State University of New York at Binghamton, Binghamton, NY, 13902, USA.
Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking neural activity with behaviors. Utilizing the self-alignment of nano-fillers in a polymeric matrix under repetitive tension, here, we introduce conductive carbon nanotubes with high aspect ratios into semi-crystalline polyvinyl alcohol hydrogels, and create electrically anisotropic percolation pathways through cyclic stretching. The resulting anisotropic hydrogel fibers (diameter of 187 ± 13 µm) exhibit fatigue resistance (up to 20,000 cycles at 20% strain) with a stretchability of 64.
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