A study of 50 children with infectious mononucleosis is presented. Results indicate that the content of large granule-containing lymphocytes corresponds to the severity of the clinical course of infectious mononucleosis. Absence of large granule-containing lymphocytes evidences severe course of the disease while their appearance favoured normal reconvalescence of patients. A high content of large granule-containing lymphocytes is an evidence of a favourable prognosis of the course of infectious mononucleosis.

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