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Value of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Identifying Osteoarticular Septic Grafts in Suspected Infective Endocarditis: Results from a Large Monocentric Cohort.
J Clin Med
September 2024
Department of Rheumatology, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, 94000 Créteil, France.
Article Synopsis
- FDG-PET/CT is valuable for diagnosing infective endocarditis (IE) and detecting additional septic sites, with prior studies revealing osteoarthritic septic grafts (OASGs) in 19.1% of IE patients.
- A larger study included 174 patients suspected of IE, finding OASGs in 27.6% of them, predominantly located in the spine, with 43.8% of cases being asymptomatic.
- The presence of OASGs was linked to musculoskeletal pain and tricuspid valve involvement, indicating that early identification could influence antibiotic treatment and orthopedic management.
Imaging of the human cochlea using micro-computed tomography before and after cochlear implantation: comparison with cone-beam computed tomography.
Eur Arch Otorhinolaryngol
July 2023
Laboratory of Biology of Osteo-Articular Tissues, SAINBIOSE Inserm U1059, Saint-Etienne, France.
Purpose: Analysis of cochlear structures and postoperative temporal bone (TB) imaging are gaining importance in the evaluation of cochlear implantation (CI°). Our aims were to explore the microarchitecture of human cochlea using micro-computed tomography (μCT), analyze electrode's placement inside cochlea after CI°, and compare pre-/post-implantation μCT scans with cone-beam CT (CBCT) scans of same TBs.
Methods: Cadaveric TBs were scanned using μCT and CBCT then underwent CI° using straight electrodes.
Recent Advances in Hydroxyapatite-Based Biocomposites for Bone Tissue Regeneration in Orthopedics.
Int J Mol Sci
August 2022
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Bone tissue is a nanocomposite consisting of an organic and inorganic matrix, in which the collagen component and the mineral phase are organized into complex and porous structures. Hydroxyapatite (HA) is the most used ceramic biomaterial since it mimics the mineral composition of the bone in vertebrates. However, this biomimetic material has poor mechanical properties, such as low tensile and compressive strength, which make it not suitable for bone tissue engineering (BTE).
View Article and Find Full Text PDFCan the Leukocyte Esterase Strip Test Predict Persistence of Periprosthetic Joint Infection at Second-Stage Reimplantation?
J Arthroplasty
March 2022
Hip Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Background: We evaluated the reliability of intraoperative assessment of leukocyte esterase (LE) in synovial fluid samples from patients undergoing reimplantation following implant removal and spacer insertion for periprosthetic joint infection (PJI). Our hypothesis was that a positive intraoperative LE test would be a better predictor of persistent infection than either serum C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR) or the combination of serum CRP and ESR.
Methods: The records of 76 patients who received a 2-stage exchange for PJI were retrospectively reviewed.
In Vitro Evaluation of Gentamicin or Vancomycin Containing Bone Graft Substitute in the Prevention of Orthopedic Implant-Related Infections.
Int J Mol Sci
December 2020
IRCCS Istituto Ortopedico Galeazzi, Laboratory of Clinical Chemistry and Microbiology, 20161 Milan, Italy.
Antibiotic-loaded bone graft substitutes are attractive clinical options and have been used for years either for prophylaxis or therapy for periprosthetic and fracture-related infections. Calcium sulfate and hydroxyapatite can be combined in an injectable and moldable bone graft substitute that provides dead space management with local release of high concentrations of antibiotics in a one-stage approach. With the aim to test preventive strategies against bone infections, a commercial hydroxyapatite/calcium sulfate bone graft substitute containing either gentamicin or vancomycin was tested against , and , harboring different resistance determinants.
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