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Effects of tri-o-cresyl phosphate on serum estrogen and progesterone concentration and ATPase activity in the shell gland of adult hens.
Chemosphere
July 2000
Department of Toxicology, Institute of Zoology, Academia Sinica, Beijing, People's Republic of China.
The activities of calcium-activated ATPase (Ca2+-ATPase) and calcium magnesium-activated ATPase (Ca2+-Mg2+-ATPase) in the shell gland, and concentrations of 17beta-estradiol (E2) and progesterone in serum were monitored, respectively, from hens orally dosed with tri-o-cresyl phosphate (TOCP) (750 mg/kg). Treated birds were monitored daily for laying and development of delayed neurotoxicity, and activities of Ca2+-ATPase and Ca2+-Mg2+-ATPase were measured at 7 and 10 days after dosing. TOCP-treated birds manifested motor deficit by 7-9 days postdosing, while hens administered vehicle exhibited no signs of delayed neurotoxicity.
View Article and Find Full Text PDFErythrocyte calcium-stimulated, magnesium-activated adenosine 5'-triphosphatase activity in essential hypertension.
J Hypertens
July 1992
Department of Medicine, Leicester Royal Infirmary, UK.
Objective: The aim of this study was to investigate the basis of reduced erythrocyte calcium-stimulated, magnesium-activated adenosine 5' triphosphatase (Ca2+, Mg(2+)-ATPase) activity in essential hypertension.
Design: Experiments were performed to establish whether the reduced erythrocyte Ca2+, Mg(2+)-ATPase activity in patients with essential hypertension, when compared with age- and sex-matched normotensive control subjects, was due to changes in enzyme properties or to an altered membrane environment.
Methods: Erythrocyte membrane Ca2+, Mg(2+)-ATPase activity was determined by measuring ATP-dependent 45Ca2+ uptake in inside-out vesicles and calcium-dependent gamma-32P ATP hydrolysis in ghost membranes, prepared from the same sample of blood.
Effects of chronic manganese treatment on rat brain regional sodium-potassium-activated and magnesium-activated adenosine triphosphatase activities during development.
Metab Brain Dis
September 1991
Department of Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello 83209-0009.
The effects of chronic manganese (Mn) treatments (1 and 10 mg MnCl2.4H2O per ml of drinking water) from conception onwards on brain regional development of sodium-potassium-activated and magnesium-activated adenosine triphosphatases (Na-K-ATPase and Mg-ATPase) were studied. The activities of these enzymes were determined in hypothalamus, cerebellum, pons and medulla, striatum, midbrain and cerebral cortex (which included the hippocampus) of Mn-treated and age-matched control rats at 5 postnatal ages.
View Article and Find Full Text PDFShortening velocity and myosin and myofibrillar ATPase activity related to myosin isoenzyme composition during postnatal development in rat myocardium.
Circ Res
August 1989
Institute of Human Physiology, University of Pavia, Italy.
The relation between functional properties of the contractile apparatus, such as shortening velocity and ATPase activity, and myosin isoenzyme composition was studied in ventricular myocardium of adult (60-90-day-old) rats and of newborn (3-day-old) and young (10- and 20-day-old) rats. In adult animals, variations of isomyosin pattern were produced by reducing food intake and by changing the thyroid state. Hyperthyroidism was induced with triiodothyronine daily injection for 15 days; hypothyroidism was induced with iodine-free diet and KClO4 in drinking water for 50-60 days.
View Article and Find Full Text PDFInhibition of synaptosome membrane-bound integral enzymes by organic solvents.
Scand J Work Environ Health
February 1989
Department of Biomedical Sciences, University of Tampere, Finland.
The possible mechanism of the depressive effect of organic solvents on the central nervous system (CNS) was studied with synaptosome membranes as a model. The changes in the activities of the membrane-bound integral enzymes acetylcholinesterase, total adenosinetriphosphatase, and magnesium-activated adenosinetriphosphatase were determined after treatment with different concentrations of organic solvents in vitro. Aromatic hydrocarbons and chlorinated aliphatic hydrocarbons inhibited all the enzyme activities concentration dependently.
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