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Pediatric Chronic Inflammatory Demyelinating Polyneuropathy: Challenges in Diagnosis and Therapeutic Strategies.
Paediatr Drugs
November 2024
Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune neurological disorder seen in both pediatric and adult populations. CIDP typically presents with progressive and persistent weakness over at least 4 weeks in addition to sensory symptoms in the extremities. Although CIDP shares common clinical features between children and adults, it sometimes presents as a distinct clinical entity in children that requires close attention and recognition.
View Article and Find Full Text PDFA 'Decrescendo' in a Woman With Ascending Paralysis: A Diagnostic Challenge.
Cureus
May 2024
Infectious Diseases, The Brooklyn Hospital Center, Brooklyn, USA.
Guillain-Barre Syndrome (GBS) is an autoimmune condition that causes muscular weakness and can be potentially life-threatening if not identified early. GBS is diagnosed definitively by cerebrospinal fluid (CSF) analysis and electromyographic (EMG) studies. Identifying illnesses that may have triggered GBS is crucial, as they could affect the course of the disease.
View Article and Find Full Text PDFAcute-onset chronic inflammatory demyelinating polyneuropathy following AstraZeneca COVID-19 vaccine: a case report.
Pan Afr Med J
April 2024
Neurology Department, Habib Bourguiba Hospital, Sfax, Tunisia.
Article Synopsis
- Reports of side effects from COVID-19 vaccinations, particularly cases of autoimmune diseases like chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barré syndrome (GBS), are increasing, though the exact relationship with vaccines is still debated.* -
- A case study from Tunisia involves a 41-year-old man who developed CIDP after receiving the Oxford/AstraZeneca vaccine, presenting symptoms 15 days post-vaccination and initially misdiagnosed as GBS.* -
- The need for awareness of CIDP as a potential post-vaccination complication is emphasized to ensure appropriate treatment and prevent long-term issues, especially since cases linked to the AstraZeneca vaccine appear to be more common.*
Sensory ataxic polyneuropathy unmasking late-onset urea cycle defect.
Clin Neurol Neurosurg
May 2024
Department of Neurology, All India Institute of Medical Sciences, Jodhpur, India. Electronic address:
Article Synopsis
- A 63-year-old man with type 2 diabetes and a history of hepatic encephalopathy presented with lower limb weakness, sensory issues, and mood swings, alongside a family history of mental disorders.
- Nerve conduction studies revealed demyelinating polyradiculoneuropathy, while MRI indicated thickened cranial and lumbosacral nerves; he was initially treated for chronic inflammatory polyneuropathy.
- After developing encephalopathy and an elevated serum ammonia level, further tests pointed to ornithine transcarbamylase (OTC) deficiency, leading to successful treatment with hemodialysis and dietary changes.
High risk and low prevalence diseases: Guillain-Barré syndrome.
Am J Emerg Med
January 2024
SAUSHEC, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA. Electronic address:
Introduction: Guillain-Barré syndrome (GBS) is a rare but serious condition that carries with it a high rate of morbidity and mortality.
Objective: This review highlights the pearls and pitfalls of GBS, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence.
Discussion: GBS is a rare immune-mediated neurologic disorder with peripheral nerve injury.
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