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Genetic Correlations Among Dental, Mandibular, and Postcranial Dimensions in Rhesus Macaques (Macaca mulatta).
Am J Biol Anthropol
January 2025
Department of Medical Anatomical Sciences, College of Osteopathic Medicine of the Pacific-Northwest, Western University of Health Sciences, Lebanon, Oregon, USA.
Objectives: Tooth dimensions typically scale with mandibular and postcranial size in primates, although the exact pattern of scaling varies. This study assesses whether correlations by tissue type, anatomical region, or function (mastication or intrasexual competition) are present and could therefore act as evolutionary constraints on tooth-jaw-body size relationships by estimating genetic and phenotypic correlations between dental, mandibular, and postcranial dimensions in rhesus macaques (Macaca mulatta).
Materials And Methods: The teeth, mandibles, and postcrania of 362 adults from the Cayo Santiago skeletal collection were measured.
miR-199a-3p mitigates simulated microgravity-induced cardiac remodeling by targeting MEF2C.
FASEB J
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Microgravity-induced cardiac remodeling and dysfunction present significant challenges to long-term spaceflight, highlighting the urgent need to elucidate the underlying molecular mechanisms and develop precise countermeasures. Previous studies have outlined the important role of miRNAs in cardiovascular disease progression, with miR-199a-3p playing a crucial role in myocardial injury repair and the maintenance of cardiac function. However, the specific role and expression pattern of miR-199a-3p in microgravity-induced cardiac remodeling remain unclear.
View Article and Find Full Text PDFA broad spectrum Shigella vaccine based on VirG multiepitope region produced in a cell-free system.
NPJ Vaccines
January 2025
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There is no vaccine available. The most advanced candidates, i.
View Article and Find Full Text PDFRelationship Between Blood Groups and Cardiovascular Diseases: Insights From an Algerian Inpatient Study.
Cureus
December 2024
Cardiology Oncology Collaborative Research Groupe, Faculty of Medicine, University of Algiers Benyoucef Benkhedda, Algiers, DZA.
Introduction: Research on the association between blood groups and cardiovascular diseases (CVDs) in Africa, including Algeria, is notably limited, with a primary focus on blood donors. This narrow scope hinders a comprehensive understanding of the genetic diversity of blood groups and their potential links to CVD risk within the African context. To bridge this knowledge gap, this study proposes to investigate the distribution of blood group genotypes and their association with CVD prevalence, aiming to enhance knowledge within the African context and contribute to global insights into the relationship between blood groups and CVD.
View Article and Find Full Text PDFAssociations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model ().
J Dev Orig Health Dis
January 2025
Yale School of Medicine, Yale Child Study Center, New Haven, CT, USA.
Early gut microbiome development may impact brain and behavioral development. Using a nonhuman primate model (), we investigated the association between social environments and the gut microbiome on infant neurodevelopment and cognitive function. Infant rhesus monkeys ( = 33) were either mother-peer-reared (MPR) or nursery-reared (NR).
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