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Metabolic characterizations of PFOS-induced disruptions in early embryonic development.
Ecotoxicol Environ Saf
March 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Department of Occupational Medicine and Environmental Health, School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Nanjing Medical University, Nanjing 211166, China. Electronic address:
Background: Perfluorooctane sulfonates (PFOS) are persistent environmental pollutants linked to developmental toxicity, but the mechanisms remain unclear. This study investigates the metabolic changes induced by PFOS exposure during early embryonic development and integrates metabolomic, transcriptomic, and molecular docking analyses to explore underlying mechanisms.
Methods: Mouse embryoid bodies (mEBs) were exposed to PFOS for 2 days, 4 days and 6 days.
Individual and mixture effects of BTEX occupational exposure with hematologic and hepatic profiles in petrochemical workers and the metabolic mechanism.
J Environ Sci (China)
August 2025
Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:
Evidence on the association of occupational exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) with hematologic and hepatic profiles were equivocal, and few studies have investigated overall effect of BTEX mixtures. Herein, significant higher concentrations (p < 0.05) of hippuric acid, 1,2-dihydroxybenzene, mandelic acid, trans, trans-muconic acid and phenylglyoxylic acid were found in petrochemical workers than the controls, in accordance with higher levels of hematologic and hepatic profiles found in petrochemical workers (p < 0.
View Article and Find Full Text PDFUtilization of UV/VUV irradiation for removal of human body fluids related pollutants in swimming pool water.
J Hazard Mater
February 2025
State Key Laboratory of Urban Water Resources and Environment (SKLUWRE), School of Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:
Human body fluids related pollutants (BFPs) are primary precursors to disinfection by-products (DBPs) in swimming pool water (SPW). This study evaluated the degradation efficiency of ultraviolet/vacuum ultraviolet (UV/VUV) technology for the removal of three typical BFPs: urea, creatinine, and hippuric acid. The results showed that UV/VUV irradiation significantly enhanced the removal of these pollutants compared to UV alone.
View Article and Find Full Text PDFExercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.
Physiol Rep
February 2025
Department of Sports Medicine, Medical Clinic VII, University Hospital Heidelberg, Heidelberg, Germany.
Little is known about the exercise-induced adaptations of the metabolome in endurance and strength athletes in comparison with sedentary subjects. In order to analyze exercise-induced effects, quantitative, targeted metabolomics (Biocrates MxP® Quant 500) were performed in plasma samples before and after one bout of endurance or resistance exercise (RE) in 12 strength-trained weightlifters (ST), 10 endurance-trained runners (ET) and 12 sedentary controls (CG) at the end of each of three characteristic training phases. Performance and anthropometric data were significantly different between CG and athletes.
View Article and Find Full Text PDFDiscovery of Noninvasive Biomarkers for Radiation Exposure via LC-MS-Based Hair Metabolomics.
J Proteome Res
March 2025
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States.
Ionizing radiation exposure from a potential nuclear energy plant leak or detonation of a nuclear weapon can cause massive casualties to both warfighters and civilians. RNA, proteins, and metabolite biomarkers in biological specimens like blood and tissue have shown potential to determine radiation dose levels. However, these biomarkers in blood and urine are short-lived, typically detectable within hours or a few days.
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