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Machine Learning Analysis of Glutamate Receptor Activity in Developing Locus Coeruleus Neurons.
Int J Neurosci
January 2025
Department of Mathematics, Payame Noor University, Tehran, Iran.
The developing brain undergoes a remarkable process of synapse production and maturation, particularly in glutamatergic synapses. In this study, we focused on the locus coeruleus (LC) nucleus, a brain region crucial for cognitive functions, to investigate the developmental changes in glutamatergic synaptic connections. Using the whole-cell patch clamp method, we recorded evoked excitatory postsynaptic currents (eEPSCs) from LC neurons in rats at ages 7, 14, and 21 days.
View Article and Find Full Text PDFEstrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications.
Aging Adv
December 2024
Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN, USA.
Estrogen hormones are primarily associated with their role as female sex hormones responsible for primary and secondary sexual development. Estrogen receptors are known to undergo age-dependent decreases due to age-related changes in hormone production. In the mitochondria, estrogen functions by reducing the production of reactive oxygen species in the electron transport chain, inhibiting apoptosis, and regulating mitochondrial DNA content.
View Article and Find Full Text PDFAge-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection.
Front Aging Neurosci
January 2025
Laboratory for Brain Development, Modulation and Repair, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, United States.
Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin.
View Article and Find Full Text PDFGenetic variation in age-dependent attractiveness in a fish with a mixed mating system.
Biol Lett
January 2025
Department of Biology, Sewanee: The University of the South, Sewanee, TN, USA.
Reproductive senescence is common across taxa and females often show a predictable decline in fecundity after maturity. Attending to these age-dependent cues could help males make optimal mate choice decisions. Here, we examined reproductive senescence and male mate choice in the androdioecious mangrove rivulus (), where self-fertilizing hermaphrodites exist with rare males.
View Article and Find Full Text PDFEmotional distress and affective knowledge representation one year after the COVID-19 outbreak.
PLoS One
January 2025
Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.
This study examines whether the detrimental effects of the COVID-19 pandemic on the affectivity of the population extend one year after the outbreak. In an online-mobile session, participants completed surveys (i.e.
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