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Article Synopsis
  • * Diagnostic tests revealed leukoplakia indicating donovanosis, while biopsy confirmed molluscum contagiosum, and blood tests were positive for HIV-1 and HSV-2.
  • * The patient was treated with acyclovir and doxycycline, alongside antiretroviral therapy, showing slow improvement over 8 weeks; the case highlights the importance of tissue smears in diagnosing granuloma inguinale in immunocompromised patients.
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Article Synopsis
  • - The rise of sexually transmitted infections (STIs) in the tropics is increasingly concerning, especially after the 2022 emergence of monkeypox, which echoes the previous spread of HIV/AIDS globally.
  • - A World Health Organization (WHO) 2023 report highlights that STIs are on the rise worldwide, and antibiotic resistance is worsening, particularly for certain bacteria, while macrolide resistance has developed in the last two decades.
  • - The potential for neglected tropical diseases like Zika and Ebola to be sexually transmitted after recovery raises new discussions about the use of pre-exposure prophylaxis (PrEP), especially for migrants and in Africa.
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Granuloma inguinale diagnosed on the bedside.

Indian J Sex Transm Dis AIDS

December 2022

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Article Synopsis
  • Donovanosis is a rare bacterial infection caused by Klebsiella granulomatosis, leading to painless, bleeding ulcers and primarily found in specific regions worldwide.
  • A case study was reported where a patient in a non-endemic area presented with a solitary genital ulcer, and initial tests did not identify the cause.
  • After several days in the hospital, a repeat tissue smear uncovered Donovan bodies, allowing for a timely diagnosis and effective treatment.
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An Ulcer by Any Other Name: Non-herpes and Non-syphilis Ulcerative Sexually Transmitted Infections.

Infect Dis Clin North Am

June 2023

Division of Infectious Diseases, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, THT 215, 1900 University Boulevard, Birmingham, AL 35294, USA.

Article Synopsis
  • Ulcerative sexually transmitted infections (STIs) present a diagnostic challenge due to similar symptoms and limited testing resources, excluding herpes and syphilis.
  • Despite a low prevalence and declining incidence of conditions like chancroid and granuloma inguinale, they still lead to significant health issues and higher HIV risk.
  • With new threats like mpox emerging, accurate identification and treatment of these STIs is crucial for public health.
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