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Anal Chem
January 2025
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China.
To facilitate on-site detection by nonspecialists, there is a demand for the development of portable "sample-to-answer" devices capable of executing all procedures in an automated or easy-to-operate manner. Here, we developed an automated detection device that integrated a magnetofluidic manipulation system and a signal acquisition system. Both systems were controllable via a smartphone.
View Article and Find Full Text PDFEnviron Technol
January 2025
Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
An increasing amount of water pollution is being caused by an increase in industrial activity. Recently, a wide range of methods, including extraction, chemical coagulation, membrane separation, chemical precipitation, adsorption, and ion exchange, have been used to remove heavy metals from aqueous solutions. The adsorption technique is believed to be the most highly effective method for eliminating heavy metals from wastewater among all of them.
View Article and Find Full Text PDFEur J Med Res
January 2025
China Medical University, Shenyang, Liaoning, China.
Background: Infrared thermography technology is a diagnostic imaging modality that converts temperature information on the surface of the human body into visualised thermograms. This technology has the capacity to intuitively detect the presence of certain abnormal conditions or foci in the human body. In recent years, the application of this technology in medicine has become increasingly extensive, especially in the areas of auxiliary diagnosis and early screening of diseases.
View Article and Find Full Text PDFBiol Direct
January 2025
Department of Clinical Laboratory, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, China.
Thioredoxin1 (TRX1) and telomerase are both attractive oncology targets that are tightly implicated in tumor initiation and development. Here, we reported that the 6-dithio-2-deoxyguanosine analog thiotert exhibits an effective cytotoxic effect on myelodysplastic syndromes (MDS) cell SKM-1 and lymphoma cell U-937. Further studies confirmed that thiotert effectively disrupts cellular redox homeostasis, as evidenced by elevated intracellular reactive oxygen species (ROS) levels, increased MnSOD, accelerated DNA impairment, and activated apoptosis signal.
View Article and Find Full Text PDFCrit Care
January 2025
Department of Neuro-Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Background And Objectives: Antibody-negative autoimmune encephalitis (AE) is a form of encephalitis characterized by the absence of detectable autoimmune antibodies, despite immunological evidence. However, data on management of patients with antibody-negative AE in the intensive care unit (ICU) are limited. This study aimed to explore the characteristics and subtypes of antibody-negative AE, assess the effects of immunotherapy, and identify factors independently associated with poor functional outcomes in patients requiring intensive care.
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