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Cushing's disease is a rare endocrine disorder characterized by hypercortisolism. Chronic elevated cortisol levels can lead to dysfunction or complications in multiple organs of systems, including cardiovascular, glucose, and bone metabolism, severely impacting patients' quality of life and posing life-threatening risks. Surgery is the first-line treatment for Cushing's disease.
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This is a personal review of my chemistry research on retirement from Teikyo University. Under the guidance of Prof. Masaji Ohno of the Faculty of Pharmaceutical Sciences, The University of Tokyo, my research career started with the synthesis of water-soluble basic natural compounds, including the first artificial bleomycin showing potent molecular-oxygen activation effects and DNA binding abilities.
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Department of Pharmacology, School of Medicine, University of Crete, Heraklion, 71003, Greece.
Alzheimer's Disease (AD) is an incurable and debilitating progressive, neurodegenerative disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is characterized by the accumulation of Aβ amyloid plaques in the microenvironment of brain cells and neurovascular walls, chronic neuroinflammation, resulting in neuronal and synaptic loss, myelin and axonal failure, as well as significant reduction in adult hippocampal neurogenesis. The hippocampal formation is particularly vulnerable to this degenerative process, due to early dysfunction of the cholinergic circuit.
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Background: Norepinephrine reuptake inhibitors such as atomoxetine (ato) can improve OSA by increasing pharyngeal muscle activity. Mineralocorticoid antagonists such as spironolactone, may potentiate the reduction of OSA severity and reduce blood pressure. We evaluated whether adding spironolactone to atomoxetine (ato-spiro) improved responses in hypertensive OSA patients.
View Article and Find Full Text PDFMolluscicidal activity and biochemical impacts of borrelidins against an aquatic invasive snail Pomacea canaliculata for crop protection.
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Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, School of Life Sciences, Huzhou University, Huzhou, Zhejiang 313000, China; Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, School of Life Sciences, Huzhou University, Huzhou, Zhejiang 313000, China; Department of Biology, Lund University, Lund 223 62, Sweden. Electronic address:
Article Synopsis
- - The golden apple snail (Pomacea canaliculata) poses significant threats to aquatic ecosystems and agriculture, leading to the exploration of effective molluscicides, particularly macrolides from microbes, due to rising antibiotic resistance issues.
- - Two borrelidins (BN1 and BN2) were tested for their ability to kill and inhibit the growth of the golden apple snail, with borrelidin BN1 showing considerable molluscicidal effectiveness similar to the common pesticide metaldehyde, but at much lower concentrations.
- - Borrelidin BN1 not only reduced snail growth and population densities but also impacted various biochemical markers in the snails, while simultaneously protecting crops like Zizania latifolia, indicating its potential as
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