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Pedicle Screw Placement in Pediatric and Adolescent Spinal Deformity Surgery: Does Tapping of the Pedicle Screw Tract Increase Safety?
J Pediatr Orthop
January 2025
Department of Orthopaedics, Division of Pediatrics and Adolescent Orthopaedic Surgery and Division of Spine Surgery, Washington University School of Medicine, St. Louis, MO.
Introduction: Since the development of pedicle screw fixation in the spine, safe placement has remained a crucial component in maximizing patient outcomes and mitigating pedicle screw-related complications. The purpose of this study is to investigate the utility of pedicle tapping in identifying pedicle breaches.
Methods: A pediatric spine surgery database was queried to identify a consecutive series of patients who underwent spinal deformity surgery utilizing pedicle screw fixation between May 2019 and October 2022.
Synthesis and Evaluation of Benzylic F-Labeled -Biphenylalkynyl Nipecotic Acid Derivatives for PET Imaging of GABA Transporter 1.
ACS Chem Neurosci
January 2025
Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, 6200 MD Maastricht, The Netherlands.
As the main inhibitory neurotransmission system, the GABAergic system poses an interesting yet underutilized target for molecular brain imaging. While PET imaging of postsynaptic GABAergic neurons has been accomplished using radiolabeled benzodiazepines targeting the GABA receptor, the development of presynaptic radioligands targeting GABA transporter 1 (GAT1) has been unsuccessful thus far. Therefore, we developed a novel GAT1-addressing radioligand and investigated its applicability as a PET tracer in rodents.
View Article and Find Full Text PDFSocial learning preserves both useful and useless theories by canalizing learners' exploration.
Proc Biol Sci
January 2025
Human Behaviour and Cultural Evolution Group, Centre for Ecology and Conservation, University of Exeter, Penryn TR10 9FE, UK.
In many domains, learning from others is crucial for leveraging cumulative cultural knowledge, which encapsulates the efforts of successive generations of innovators. However, anecdotal and experimental evidence suggests that reliance on social information can reduce the exploration of the problem space. Here, we experimentally investigate the extent to which cultural transmission fosters the persistence of arbitrary solutions in a context where participants are incentivized to improve a physical system across multiple trials.
View Article and Find Full Text PDFHow Droplets Dry on Stretched Soft Substrates.
ACS Nano
January 2025
Leibniz Institute of Polymer Research, Dresden 01069, Germany.
Droplet evaporation on solid substrates is a ubiquitous phenomenon and is relevant in many natural and industrial processes. Whereas it has been reported that the evaporation process is sped up on soft substrates compared with that on hard substrates, no attempt has been made in exploring how substrate stretching affects droplet evaporation and evaporative deposition patterns. Here, we systematically investigate the contact line dynamics of droplets evaporating on substrates with different stiffnesses and stretching ratios and the structures of the evaporative deposition patterns of nanoparticles.
View Article and Find Full Text PDFElucidating the therapeutic potential of indazole derivative bindarit against K-ras receptor: An analysis using molecular dynamics exploration.
Biochem Biophys Rep
March 2025
School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Ras gene is frequently mutated in cancer. Among different subtypes of Ras gene, K-Ras mutation occurs in nearly 30 % of human cancers. K-Ras mutation, specifically K-Ras (G12D) mutation is prevalent in cancers like lung, colon and pancreatic cancer.
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