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Protective effects of electroacupuncture on senile osteoporosis in rats.
Acupunct Med
December 2024
Department of Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- - The study aimed to assess the protective effects of electroacupuncture (EA) on osteoporosis in elderly rats and examine the mechanisms behind it.
- - Aged male rats underwent EA treatment for 8 weeks, showing significant increases in bone formation markers and improvements in bone density compared to non-treated aged rats.
- - The findings suggest that EA helps prevent bone loss in aged rats by enhancing bone formation through the activation of the Wnt/β-catenin signaling pathway, indicating potential therapeutic benefits for senile osteoporosis.
Ayurvedic Management of Presbycusis (Project TOPMAC): Protocol for an Exploratory Randomized Controlled Trial.
JMIR Res Protoc
September 2024
Central Council for Research in Ayurvedic Sciences, New Delhi, India.
Background: Presbycusis is characterized by sensorineural hearing loss in both ears at high frequencies, which affects more than half of the older adults by the age of 75 years and is often accompanied by tinnitus and cognitive deterioration. Unfortunately, there are no treatments available to restore hearing loss. Treatment mainly focuses on improving the quality of life and communication with hearing aids.
View Article and Find Full Text PDFGuanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization.
Drug Des Devel Ther
September 2024
Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China.
Article Synopsis
- Ischemic stroke (IS) leads to serious health issues, and current rehabilitation options are insufficient, but the Guanxinning tablet (GXNT), made from Danshen and Chuanxiong, shows promise in protecting the brain from IS damage.
- Researchers investigated GXNT's effects on neurological function, brain lesions, and blood-brain barrier integrity, using advanced techniques like transcriptome sequencing to understand the underlying mechanisms.
- Results revealed that GXNT significantly improved functional outcomes, reduced brain injury, and corrected abnormal protein expressions linked to inflammation, indicating its potential as a treatment for post-IS complications.
Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle.
J Tradit Complement Med
September 2024
Hebei Medical University, Shijiazhuang, 050017, China.
Background And Aim: Muscular atrophy is one of the most common age-related conditions characterized by the deterioration of skeletal muscle structures and impaired functions. It is associated with cellular senescence and chronic inflammation, which impair the function of muscle stem cells. Bazi Bushen (BZBS) is a patent compound Chinese medicine that has been shown to have anti-aging effects in various animal models.
View Article and Find Full Text PDFUpdates in Alzheimer's disease: from basic research to diagnosis and therapies.
Transl Neurodegener
September 2024
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and intracellular accumulation of hyperphosphorylated tau (pTau) as neurofibrillary tangles. Clinically, AD patients show memory deterioration with varying cognitive dysfunctions. The exact molecular mechanisms underlying AD are still not fully understood, and there are no efficient drugs to stop or reverse the disease progression.
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