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Intravenous and intracranial GD2-CAR T cells for H3K27M diffuse midline gliomas.
Nature
November 2024
Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. ). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models.
View Article and Find Full Text PDFSuperior cervical ganglionectomy attenuates vascular remodeling in spontaneously hypertensive rats.
J Hypertens
February 2025
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, and Department of Physiology.
Article Synopsis
- The study investigates the role of excessive sympathetic activity in causing vascular remodeling in hypertension by performing local sympathetic denervation through superior cervical ganglionectomy (SCGx) on two types of rats: Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).
- Results showed that SCGx did not significantly affect blood pressure or heart rate but reduced vascular remodeling in specific arteries associated with the sympathetic nervous system, while it had minimal impact on non-sympathetic arteries.
- The findings suggest that sympathetic overactivity is a key factor in vascular changes associated with hypertension, as evidenced by improvements in blood flow and reduced oxidative stress and inflammation in denervated arteries of SHR
Ultrasound-guided trigeminal nerve approach at the level of the pterygopalatine fossa in cat cadavers.
Vet Anaesth Analg
October 2024
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Objective: To describe an ultrasound-guided suprazygomatic approach to the trigeminal nerve block in cat cadavers.
Study Design: Prospective descriptive study.
Animals: Ten feline cadaver heads.
[A case of numb chin syndrome caused by postcentral gyrus infarction].
Rinsho Shinkeigaku
September 2024
Department of Neurology, Chubu Rosai Hospital.
We report a case of numb chin syndrome caused by a small cortical infarction in the postcentral gyrus. A 67-year-old man suddenly developed numbness in his right lower lip and the chin. There were no apparent abnormal neurological symptoms other than numbness.
View Article and Find Full Text PDFRole of pterygopalatine ganglion in regulating isoflurane-induced cerebral hyper-perfusion.
J Cereb Blood Flow Metab
August 2024
Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Article Synopsis
- Cerebral perfusion is influenced by neural mechanisms, systemic blood flow, and metabolic activity, and some anesthetics like isoflurane can actually increase cerebral blood flow, raising risks during surgery.
- Research using laser imaging showed that isoflurane administration leads to a temporary increase in cerebral perfusion in mice, revealing a strong parasympathetic influence over blood vessels.
- The study found that isoflurane activates certain neurons in the pterygopalatine ganglion, with effects on cerebral perfusion that vary based on the type of cholinergic receptor being blocked or activated.
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