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Fruit Extract: Bioactive Compounds, ADMET Analysis, and Molecular Docking with Penicillin-Binding Protein 2a Transpeptidase of Methicillin-Resistant .
Curr Issues Mol Biol
January 2025
Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
is a rich source of bioactive molecules and thrives in Mediterranean and desert climate regions worldwide. In this study, methanolic HPLC fractions were evaluated for bioactive compounds and PBP2a transpeptidase inhibitors against methicillin-resistant (MRSE). Among the collected HPLC fractions, F02 of the methanol extract demonstrated potential activity against MRSE01 (15 ± 0.
View Article and Find Full Text PDFProbing Antimicrobial Activity and Mechanism of Action of a Bile Acid-Derived Antibiotic.
ACS Omega
January 2025
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Antibiotics have revolutionized medicine, saving countless lives since the introduction of penicillin. However, antimicrobial resistance has challenged their efficacy, prompting ongoing efforts to develop new antibiotics. This study explores the antimicrobial effects of a bile acid derivative, BA-3/4-Butyl.
View Article and Find Full Text PDFDegradation mechanism of PGNa by the immobilized degrading enzymes from magnetic fermentation residue biochar.
Sci Total Environ
January 2025
Engineering Research Center of Resource Utilization of Carbon-containing Waste with Carbon Neutrality, Ministry of Education, East China University of Science and Technology, Shanghai 200237, China; State Key Laboratory of Coal Liquification, Gasification and Utilization with High Efficiency and Low Carbon Technology, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
The development of a method to efficiently remove high concentrations of penicillin G sodium (PGNa) from the environment is important for human and animal health and safety. In this study, the degradative enzymes were immobilized by adsorption using biochar from penicillin fermentation waste residue, which could efficiently remove PGNa (900 mg/L) from an aqueous solution, with a removal rate of 99.84 % within 20 min.
View Article and Find Full Text PDFIn vitro evaluation of the antimicrobial effect of ZnO:9Ag nanoparticle and antibiotics on standard strains of Leptospira spp.
Microb Pathog
February 2025
Faculty of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, 38402-018, Brazil.
Silver nanoparticles are recognized for potent antimicrobial properties against pathogenic bacteria, crucial in addressing the severity of leptospirosis, where an ideal treatment is lacking. This study focuses on assessing the antimicrobial efficacy of silver-doped zinc oxide nanoparticles (ZnO:9Ag) on standard Leptospira spp. strains (six species and ten serovars).
View Article and Find Full Text PDFUse of antibiotics in patients with chronic kidney disease: evidence from the real world.
Expert Opin Drug Saf
December 2024
Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S A, Pereira, Risaralda, Colombia.
Background: Most antibiotics require dose adjustments in patients with chronic kidney disease (CKD) to avoid accumulation and toxicity. The aim was to characterize the use of systemic antibiotics in a group of patients with CKD and to adjust the dose according to the glomerular filtration rate (GFR).
Research Design And Methods: Observational study of patients with a diagnosis of CKD who received antibiotics between January-2021 July 2022.
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