With continued development of new chemicals and genetically engineered microbes as potential agents for terrorism and industrial development, there is a great need for the continued development and application of quantitative structure activity relationships (QSARs) and virulence factor activity relationships (VFARs). Development and application of QSARs and VFARs will facilitate efficient and streamlined use of dwindling resources and assessment of risks associated with exposures to chemical and biological agents. To facilitate the continued development of QSARs and VFARs at US Environmental Protection Agency, a two day workshop was organized June 20-21, 2006, in Cincinnati, OH, USA. This article summarizes the workshop report by highlighting the importance of continued QSAR research, the current state of VFAR science, and the guidance provided to the National Homeland Security Research Center and National Risk Management Research Laboratory by an expert panel for the continued use and development of computational approaches.
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http://dx.doi.org/10.1080/10629360802348944 | DOI Listing |
JMIR Form Res
January 2025
Private Practice, Ballito, South Africa.
Background: Barriers to mental health assessment and intervention have been well documented within South Africa, in both urban and rural settings. Internationally, evidence has emerged for the effectiveness of technology and, specifically, app-based mental health tools and interventions to help overcome some of these barriers. However, research on digital interventions specific to the South African context and mental health is limited.
View Article and Find Full Text PDFJMIR Form Res
January 2025
Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Background: Opioid medications are important for pain management, but many patients progress to unsafe medication use. With few personalized and accessible behavioral treatment options to reduce potential opioid-related harm, new and innovative patient-centered approaches are urgently needed to fill this gap.
Objective: This study involved the first phase of co-designing a digital brief intervention to reduce the risk of opioid-related harm by investigating the lived experience of chronic noncancer pain (CNCP) in treatment-seeking patients, with a particular focus on opioid therapy experiences.
J Med Internet Res
January 2025
School of Clinical Sciences, Monash University, Melbourne, Australia.
Background: eHealth interventions can favorably impact health outcomes and encourage health-promoting behaviors in children. More insight is needed from the perspective of children and their families regarding eHealth interventions, including features influencing program effectiveness.
Objective: This review aimed to explore families' experiences with family-focused web-based interventions for improving health.
ACS Appl Mater Interfaces
January 2025
Electrical & Computer Engineering Department, Montana State University, Bozeman, Montana 59717, United States.
Interfacial mechanical stability between silicon (Si) and the current collector is crucial when high areal-loading of Si is demanded as intense stress develops at the interface due to its extreme volume alteration during the lithiation-delithiation process. Therefore, we propose using a thin, rough, porous, and highly conductive carbon nanotube network (CNT-N) as a buffer layer between the Si and current collector that provides abundant anchor sites for Si nanoparticles. The strong and elastic CNT-N, which is not involved directly in the lithiation process, reduces stress at interfaces between the Si and CNT-N and the CNT-N and current collector.
View Article and Find Full Text PDFOcul Immunol Inflamm
January 2025
Universiti Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Purpose: To shed light on one of the ocular adverse effects related to pembrolizumab.
Method: Case report and literature review.
Result: A 53-year-old gentleman with underlying Stage III B renal cell carcinoma with lung metastasis and gout presented in June 2021 with bilateral red eyes following Coronavirus disease (COVID-19) vaccination.
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