Objective: Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia.
Patients And Methods: We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing.
Results: We found no variation between the normal subjects and the preeclamptic patients.
Conclusion: The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia.
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| http://dx.doi.org/10.1007/BF03346418 | DOI Listing |
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