Purpose: To report on the intraocular use of a steroid slow-release device in an attempt to avoid multiple intraocular triamcinolone injections in chronic sympathetic ophthalmia.
Methods: A 47-year-old patient with sympathetic ophthalmia had received 17 intravitreal triamcinolone injections to suppress the uveitis, to increase intraocular pressure, and to reduce systemic anti-inflammatory medication. To avoid the frequent reinjections combined with the temporary reduction in vision and potential risk of infection and a recurrence of sympathetic ophthalmia, a slow-release device of 2.1-mg fluocinolone acetonide was intravitreally implanted.
Results: During the follow-up of 11 months after the procedure, intraocular pressure stabilized at 12 to 18 mmHg and visual acuity at 0.40 to 0.50. The systemic immunosuppressive therapy was stopped, and consequently, the insulin treatment could be halted.
Conclusions: Despite the limitations of a single case report, the results suggest that an intravitreal slow-release device of fluocinolone may be an alternative to repeatedly administered intravitreal triamcinolone injection for the long-term treatment of sympathetic ophthalmia. The intraocular slow-release application of steroids has enabled patients to live free from diabetic treatment and immunosuppressive medication after 21 years of systemic immunosuppressive therapy with secondary Cushing disease including diabetes mellitusand arterial hypertension.
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http://dx.doi.org/10.1177/112067210801800531 | DOI Listing |
BMC Oral Health
December 2024
Department of Microbiology, Medical Research Institute, Alexandria University, Azarita, Egypt.
Background: Periodontitis is a chronic inflammatory disease caused by the accumulation of biofilm. Antimicrobials have been used as adjuncts to non-surgical periodontal therapy. However, systemic antibiotics often require large dosages to achieve suitable concentrations at the disease site.
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Department of Epidemiology and Public Health, Tokyo Dental College, Tokyo 101-0061, Japan.
An intraoral fluoride-releasing device (IFRD) is a cost-effective tool for introducing fluoride into the oral cavity. It allows prolonged uptake of low concentrations of fluoride into teeth. We developed a new IFRD using 3D additive manufacturing and a new low-release fluoride gel.
View Article and Find Full Text PDFEnviron Res
February 2025
College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou, 730070, Gansu, PR China; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Lanzhou, 730070, Gansu, PR China.
In Fenton-like systems, a slow-release of hydrogen peroxide (HO) is of great value in improving the sustainable treatment of pollutants. In this study, calcium peroxide (CaO) was first synthesized by different methods, and its slow-release performance of HO was evaluated. Then CaO@PDA composites (referred to as CP-X, X represent the mass ratio of Polydopamine (PDA) to CaO were prepared by using a simple precipitation method.
View Article and Find Full Text PDFJ Nanobiotechnology
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Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release.
View Article and Find Full Text PDFInt J Biol Macromol
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School of Basic Medicine, Jinzhou Medical University, No.40, Section 4, Road Songpo, Jinzhou, Liaoning 121001, PR China. Electronic address:
The management of diabetic wounds presents significant challenges due to persistent inflammation, microenvironmental disruptions, and impaired angiogenesis. To address these issues, this study developed a multifunctional chondroitin sulfate sponge (CSP@Cu-Mg) with anti-inflammatory properties, hemostatic effects, effusion absorption, and enhanced healing promotion. Through ion crosslinking, MgO and CuO were incorporated into the interpenetrating network structure of chondroitin sulfate and acellular dermal matrix, resulting in a sponge with impressive liquid absorption capacity (3450 %) and porosity (83 %).
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