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Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities.
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Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, 00161, Rome, Italy.
Currently, the synthesis of bioactive sulfonamides using amino acid as a starting reagent has become an area of research interest in organic chemistry. Over the years, an amine-sulfonyl chloride reaction has been adopted as a common step in traditional sulfonamide synthetic methods. However, recent developments have shown amino acids to be better precursors than amines in the synthesis of sulfonamides.
View Article and Find Full Text PDFModulation of copper-induced neurotoxicity by monoisoamyl 2,3-dimercaptosuccinic acid loaded nanoparticles through inhibition of mitophagy and reduction of oxidative stress in SH-SY5Y cells.
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Era College of Pharmacy, Era University, Sarfarajgung, Lucknow-Hardoi Road, Lucknow, Uttar Pradesh, India.
Copper (Cu) dysregulation, often stemming from ATP7B gene mutations, exacerbates neurological disorders like Huntington's, Alzheimer's, and Parkinson's diseases. Monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA) shows promise in mitigating Cu induced neurotoxicity by chelating intracellular Cu ions, reducing oxidative stress, and restoring antioxidant enzyme function. However, challenges such as poor bioavailability hinder its therapeutic efficacy.
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View Article and Find Full Text PDFCharacterization and interactions between piperine and ezetimibe in their Anti-hyperlipidemic efficacy using Biopharmaceutics and Pharmacokinetics.
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Department of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, P.O. Box 71, Ishaka - Bushenyi, Uganda.
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View Article and Find Full Text PDFDeposition of sulfur by Spartina alterniflora promoted its ecological adaptability in cadmium-polluted coastal wetlands.
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Jingjiang College, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013 China; Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen 361102 China. Electronic address:
Invasive Spartina alterniflora poses a significant threat to coastal wetland ecosystems. This study investigated the role of sulfur (S) in facilitating the invasion of S. alterniflora in cadmium (Cd)-contaminated coastal wetlands by greenhouse-control-experiment.
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