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| http://dx.doi.org/10.1007/s12263-007-0032-7 | DOI Listing |
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Conformational dynamics in specialized CH zinc finger domains enable zinc-responsive gene repression in S. pombe.
Protein Sci
February 2025
Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA.
Loz1 is a zinc-responsive transcription factor in fission yeast that maintains cellular zinc homeostasis by repressing the expression of genes required for zinc uptake in high zinc conditions. Previous deletion analysis of Loz1 found a region containing two tandem CH zinc-fingers and an upstream "accessory domain" rich in histidine, lysine, and arginine residues to be sufficient for zinc-dependent DNA binding and gene repression. Here we report unexpected biophysical properties of this pair of seemingly classical CH zinc fingers.
View Article and Find Full Text PDFPrecision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of MASLD.
Liver Int
February 2025
Department of Epidemiology and Data Science, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Background And Aims: The performance of non-invasive liver tests (NITs) is known to vary across settings and subgroups. We systematically evaluated whether the performance of three NITs in detecting advanced fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) varies with age, sex, body mass index (BMI), type 2 diabetes mellitus (T2DM) status or liver enzymes.
Methods: Data from 586 adult LITMUS Metacohort participants with histologically characterised MASLD were included.
Low dietary diversity and associated factors among adult people with HIV patients attending ART clinics of Ethiopia. Systematic review and meta-analysis.
AIDS Res Ther
January 2025
Department of Nursing, College of Medicine and Health Science, Debre Berhan University, Debre Berhan, Ethiopia.
Introduction: Dietary diversity is the utilization of food and food groups consumed by individuals over 24 h, which is an indicator of a diet's micronutrient adequacy. Dietary management in people with HIV patients is the key to sustaining their day-to-day activities and contributing to their lively hood. The level of dietary diversity among HIV-positive patients in Ethiopia shows considerable variation, ranging from 29 to 71.
View Article and Find Full Text PDFIncreased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation.
Genes Environ
January 2025
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Yada 52- 1, Suruga-ku, Shizuoka, 422-8526, Japan.
Background: Skin is exposed to various environmental factors throughout life, and some of these factors are known to contribute to skin aging. Long-term solar UV exposure is a well-known cause of skin aging, as is cigarette smoke, which contains a number of chemicals. In this study, combined effect of UVA and cigarette sidestream smoke (CSS) on matrix metalloproteinase-1 (MMP-1) induction was investigated.
View Article and Find Full Text PDFImpact of geographical variation on nutritional and antioxidant properties of Basella alba L. from Sri Lanka.
BMC Plant Biol
January 2025
Department of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, SLIIT Malabe Campus, Malabe, 10115, Sri Lanka.
Background: Basella alba L. (Malabar spinach) is a widely consumed leafy vegetable, well known for its nutritional and therapeutic properties. These properties arise from the availability of essential nutrients, phytochemicals, and antioxidant potential, which may vary depending on environmental factors induced by the geographical location.
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