Neurons in the auditory cortex can lock to the fine timing of acoustic stimuli with millisecond precision, but it is not known whether this precise spike timing can be used to guide decisions. We used chronically implanted microelectrode pairs to stimulate neurons in the rat auditory cortex directly and found that rats can exploit differences in the timing of cortical activity that are as short as 3 ms to guide decisions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062077 | PMC |
| http://dx.doi.org/10.1038/nn.2211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain.
Pain Rep
February 2025
Department of Occupational Therapy, Graduate School of Rehabilitation Science, Osaka Metropolitan University, Osaka, Japan.
Introduction: Chronic low back pain (CLBP) is a global health issue, and its nonspecific causes make treatment challenging. Understanding the neural mechanisms of CLBP should contribute to developing effective therapies.
Objectives: To compare current source density (CSD) and functional connectivity (FC) extracted from resting electroencephalography (EEG) between patients with CLBP and healthy controls and to examine the correlations between EEG indices and symptoms.
Extracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague-Dawley Rats.
Mol Neurobiol
January 2025
Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
This study aimed to investigate the impact of early childhood chronic stress on the development of the brain extracellular matrix (ECM) and how alterations in the ECM following early-life adversity (ELA) affect auditory learning and cognitive flexibility. ELA was induced through a combination of maternal separation and neonatal isolation in male Sprague-Dawley rats, and the success of the ELA model was assessed behaviorally and biochemically. A cortex-dependent go/no-go task with two phases was used to determine the impact of ELA on auditory learning and cognitive flexibility.
View Article and Find Full Text PDFNeural Dynamics of the Processing of Speech Features: Evidence for a Progression of Features from Acoustic to Sentential Processing.
J Neurosci
January 2025
Department of Electrical and Computer Engineering, University of Maryland, College Park, MD, 20742
When we listen to speech, our brain's neurophysiological responses "track" its acoustic features, but it is less well understood how these auditory responses are enhanced by linguistic content. Here, we recorded magnetoencephalography (MEG) responses while subjects of both sexes listened to four types of continuous-speech-like passages: speech-envelope modulated noise, English-like non-words, scrambled words, and a narrative passage. Temporal response function (TRF) analysis provides strong neural evidence for the emergent features of speech processing in cortex, from acoustics to higher-level linguistics, as incremental steps in neural speech processing.
View Article and Find Full Text PDFThe astrocytic zinc transporter ZIP12 is a synaptic protein that contributes to synaptic zinc levels in mouse auditory cortex.
J Neurosci
January 2025
Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV, USA.
Synaptically released zinc is a neuronal signaling system that arises from the actions of the presynaptic vesicular zinc transporter protein ZnT3. Mechanisms that regulate the actions of zinc at synapses are of great importance for many aspects of synaptic signaling in the brain. Here, we identify the astrocytic zinc transporter protein ZIP12 as a candidate mechanism that contributes to zinc clearance at cortical synapses.
View Article and Find Full Text PDFHemispheric asymmetries in the auditory cortex reflect discriminative responses to temporal details or summary statistics of stationary sounds.
Cortex
January 2025
Molecular Mind Lab, IMT School for Advanced Studies Lucca, Italy. Electronic address:
The processing of stationary sounds relies on both local features and compact representations. As local information is compressed into summary statistics, abstract representations emerge. Whether the brain is endowed with distinct neural architectures predisposed to such computations is unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!