Natural polysaccharides, due to their outstanding merits, have received more and more attention in the field of drug delivery systems. In particular, polysaccharides seem to be the most promising materials in the preparation of nanometeric carriers. This review relates to the newest developments in the preparation of polysaccharides-based nanoparticles. In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crosslinking, polyelectrolyte complex, and the self-assembly of hydrophobically modified polysaccharides.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.addr.2008.09.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomacromolecules-based nanoparticle formulations for the treatment of osteoporosis: A bibliometric analysis.
Int J Biol Macromol
December 2024
Department of Orthopedics, Shengjing Hospital of China Medical University, Liaoning 110000, China. Electronic address:
Article Synopsis
- A bibliometric analysis of nanoparticle formulations, specifically focusing on polysaccharides for osteoporosis treatments, examined 141 publications from 2009 to 2024, indicating a growing interest in this research area.
- Of the total publications, 117 were original research articles, with 61 specifically oriented towards polysaccharide-based nanoparticles for drug delivery.
- The study revealed key research areas such as pharmacology, materials science, and nanotechnology, with significant contributions from countries like China, India, and Egypt, highlighting a collaborative global effort and outlining future challenges and perspectives in the field.
Nasal administration of polysaccharides-based nanocarrier combining hemoglobin and diferuloylmethane for managing diabetic kidney disease.
Int J Biol Macromol
December 2024
Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan; Taipei Medical University Research Center of Urology and Kidney, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan; Department of Urology, Shuang Ho Hospital, Taipei Medical University, 291 Zhongzheng Road, Zhonghe District, New Taipei City 23561, Taiwan. Electronic address:
The management of diabetic kidney disease (DKD) faces challenges stemming from intricate pathologies and suboptimal biodistributions during drug delivery. Although clinically available anti-inflammatory agents hold considerable promise for treating DKD, their therapeutic effectiveness is limited when utilized in isolation. To address this limitation, we introduced a novel self-oriented nanocarrier termed F-GCS@Hb-DIF, designed to synergistically integrate the therapeutic diferuloylmethane (DIF), the polysaccharide fucoidan/glycol chitosan (F-GCS), and phototherapeutic hemoglobin (Hb).
View Article and Find Full Text PDFConstruction and performance evaluation of polyguluronic acid polysaccharides-based drug delivery systems.
Colloids Surf B Biointerfaces
October 2024
College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, People's Republic of China. Electronic address:
Polysaccharides have garnered significant attention as potential nanoparticle carriers for targeted tumor therapy due to their excellent biodegradability and biocompatibility. Polyguluronic acid (PG) is a homogeneous acidic polysaccharide fragment derived from alginate, which is found in brown algae, possesses excellent bioactivities, unique properties. This study explored the immunomodulatory activity of PG and developed PG-based nanogels through modified disulfide bonds and Ca dual crosslinking.
View Article and Find Full Text PDFAdvances in herbal polysaccharides-based nano-drug delivery systems for cancer immunotherapy.
J Drug Target
December 2024
Department of Pharmaceutics, School of Pharmaceutical Sciences, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Article Synopsis
- * Researchers are exploring Nano Drug Delivery Systems (NDDS) for better targeting of immunotherapy drugs, though traditional systems face issues like poor bioavailability and high toxicity.
- * Herbal Polysaccharides (HPS) from Chinese herbs show promise as a safer alternative, thanks to their low toxicity and beneficial properties, making them suitable for use in nanomedicines aimed at enhancing cancer treatment efficacy.
Roles of polysaccharides-based nanomaterials in food preservation and extension of shelf-life of food products: A review.
Int J Biol Macromol
December 2023
Department of Food Science and Technology, Seoul Women's University, 621, Hwarangro, Nowon-gu, Seoul 01797, Republic of Korea. Electronic address:
In food production sectors, food spoilage and contamination are major issues that threaten and negatively influence food standards and safety. Several physical, chemical, and biological methods are used to extend the shelf-life of food products, but they have their limitations. Henceforth, researchers and scientists resort to novel methods to resolve these existing issues.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!