Purpose: Bisphosphonates are used for inhibiting bone resorption in several diseases. In this experimental study, the effects of alendronate on the mandibular distraction gap in rabbits at 2 different rates were evaluated.
Materials And Methods: The study was performed using 15 New Zealand white rabbits. Group 1 consisted of animals with distraction at the rate of 1 mm/day. Group 2 consisted of animals with distraction at the rate of 2 mm/day. These experimental groups had a postoperative alendronate injection during the first 3 days of their distraction phase. Group 3 consisted of animals with distraction at the rate of 1 mm/day, without alendronate injections. Distraction was performed on only the left sides of all animals until a gap of 10 mm was achieved. On postoperative day 45, the animals were sacrificed, and the mandibles of all animals were evaluated radiographically and histologically, and with dual-energy x-ray absorptiometry (DEXA). Radiographic images were also evaluated using transmission densitometry (TD).
Results: Histologically, bone healing was found to be significantly accelerated in groups 1 and 2 compared with group 3 (P < .05). Bone healing was superior in group 2, but the difference was not statistically significant compared with group 1. The TD results revealed no statistical difference between experimental groups, whereas the results for group 2 showed significantly denser osteogenic formation in the distraction gap compared with group 3. There was a significant increase in mean bone mineral density in the experimental groups compared with the control group.
Conclusion: Histologic, TD, and DEXA results showed that alendronate injections during the distraction phase may be effective in accelerating new bone formation in the distraction gap in rabbit mandibles. The TD results also support the concept that an administration of alendronate may allow a 2 mm/day elongation instead of 1 mm/day in the rabbit mandible.
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http://dx.doi.org/10.1016/j.joms.2008.06.023 | DOI Listing |
Adv Simul (Lond)
December 2024
Harvard Medical School, Boston, USA.
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Addictions and related-Research Group, Sangath, Porvorim, Goa, India.
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November 2024
German Research Center for Artificial Intelligence, Saarbrücken, Germany.
Introduction: Individuals with diverse motor abilities often benefit from intensive and specialized rehabilitation therapies aimed at enhancing their functional recovery. Nevertheless, the challenge lies in the restricted availability of neurorehabilitation professionals, hindering the effective delivery of the necessary level of care. Robotic devices hold great potential in reducing the dependence on medical personnel during therapy but, at the same time, they generally lack the crucial human interaction and motivation that traditional in-person sessions provide.
View Article and Find Full Text PDFKnee
January 2025
Ogori Daiichi General Hospital, Yamaguchi City, Yamaguchi, Japan.
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November 2024
Institute of Sociology, Faculty of Behavioral Science, Chemnitz Univercity of Technology, Chemnitz, Germany.
This study is dedicated to the investigation of technostress caused by self-tracking in performance-oriented amateur sports and thus addresses a significant research gap in the understanding of stress factors operating in this specific context. Although technostress in occupational and private settings has been extensively researched, there is a lack of knowledge about the effects and specifics of technostress caused by the use of self-tracking technologies such as wearables and performance monitoring apps in sports. A total of 16 stress factors were identified, eight of which - information overload, distraction, unavailability, loss of control, lack of sense of achievement, unreliability, complexity and self-monitoring - are already known from the professional context and were transferred to the sports context.
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