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Brown Tumors: The Hidden Face of Primary and Renal Hyperparathyroidism Amid Real-Life Settings.
J Clin Med
June 2024
Department of Nephrology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Brown tumors, an exceptional bone complication of severe primary (PHP) or renal (secondary) hyperparathyroidism (RHP), are caused by long-standing, elevated parathormone (PTH)-induced osteoclast activation causing multinucleated giant cell conglomerates with hemosiderin deposits in addition to the local production of cytokines and growth factors. We aim to present an adult case series including two females displaying this complication as part of a multidisciplinary complex panel in high PTH-related ailments. The approach was different since they had distinct medical backgrounds and posed a wide area of challenges amid real-life settings, namely, a 38-year-old lady with PHP and long-term uncontrolled hypercalcemia (with a history of pregnancy-associated PHP, the removal of a cystic jaw tumor, as well as a family and personal positive diagnosis of polycystic kidney disease, probably a PHP-jaw tumor syndrome), as well as, a 26-year-old woman with congenital single kidney and chronic renal disease-associated RHP who was poorly controlled under dialysis and developed severe anemia and episodes of metabolic acidosis (including one presentation that required emergency hemodialysis and was complicated with convulsive seizures, followed by resuscitated respiratory arrest).
View Article and Find Full Text PDFBeneath the Surface: Exploring Hidden Threats of Long-Term Corticosteroid Therapy to Bone Density.
Cureus
February 2024
General Practice, Alaziziyah Primary Health Care Center, Tabuk, SAU.
Within the field of medical treatments, corticosteroids are potent substances that efficiently reduce inflammation and immunological responses, making them essential for the management of a wide range of medical ailments. However, continued use of these synthetic drugs presents a serious risk: the onset of osteoporosis brought on by corticosteroids. Determining the complex pathways by which corticosteroids cause a general disturbance in bone metabolism, suppress osteoblast function, increase osteoclast activity, and upset the delicate balance of bone remodelling emphasizes the need for all-encompassing management and prevention approaches.
View Article and Find Full Text PDFExploring nature's hidden treasure: Unraveling the untapped phytochemical and pharmacological potentials of L. - A hidden gem in the Lamiaceae family.
Heliyon
January 2024
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955, Saudi Arabia.
Folk medicine, rooted in historical practice, has long been used for medicinal purposes, emphasizing the need to ensure the safety, quality, and efficacy of herbal medicines. This imperative has grown over time, prompting collaborative efforts to document historical records and preserve invaluable knowledge of medicinal plants. The Lamiaceae (Labiatae) family, renowned for its rich assortment of medicinal plants characterized by high concentrations of volatile oils, stands out in this regard.
View Article and Find Full Text PDFA novel automated Parkinson's disease identification approach using deep learning and EEG.
PeerJ Comput Sci
November 2023
Department of Computer and Self Development, Prince Sattam bin Abdulaziz University, AlKharj, Saudi Arabia.
Article Synopsis
- Parkinson's disease (PD) mainly affects older people and causes symptoms like shaking, stiff muscles, and slow movement.
- Scientists don’t know exactly what causes PD, but both genes and the environment play a role; early detection is important for slowing its progression.
- A new deep learning model called DLBLSTM can help identify PD more accurately using EEG data, achieving a super high accuracy rate of 99.6%.
Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD).
Biomedicines
November 2023
Department of Ophthalmology, Jones Eye Institute, Pat & Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.
In recent years, there has been a captivating focus of interest in elucidating the intricate crosstalk between adiponectin (APN), a versatile fat-associated adipokine and ocular pathologies. Unveiling the intricate relationship between adipocytokine APN and its receptors (AdipoRs) with aging eye disorders has emerged as a fascinating frontier in medical research. This review article delves into this connection, illuminating the hidden influence of APN on retinal health.
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