A route enabling the synthesis of the stereo-triad of rishirilide B (1) from 2-hydroxy-3-methylnaphthalene-1,4-dione, is reported. Key transformations include the regioselective 1,2-Grignard addition to a tautomeric mixture of o- and p-quinones, regioselective carbamoylation of a tautomeric mixture, and a synopsis of the methods explored to convert various terminal vinyl ethers into the corresponding carboxylic acid by cleavage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564814 | PMC |
| http://dx.doi.org/10.1055/s-2006-950188 | DOI Listing |
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