A model [6 + 5] segment coupling process involving a C-terminal valine hexapeptide acid and a resin-attached pentapeptide amide which N-terminated in a hindered Aib unit was examined using a variety of HOAt-derived coupling reagents. Best results were observed with HAPyU in DCM solvent in which loss of configuration amounted to 5.8%.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2344146 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2007.07.215 | DOI Listing |
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