AI Article Synopsis
- - Acryloyl chlorides, aldehydes, and PhSLi can undergo a direct aldol cascade reaction using MgBr2 x OEt2 to create thioester enolates, leading to the formation of alpha-alkenyl-beta'-hydroxy thioesters through oxidative elimination.
- - This method is quick, efficient, and broadly applicable, even for beta-substituted acryloyl chlorides.
- - It offers a valuable alternative to the Morita-Baylis-Hillman reaction, expanding the range of synthetic possibilities available to chemists.
Article Abstract
Acryloyl chlorides, aldehydes, and PhSLi undergo a direct aldol cascade sequence in the presence of MgBr2 x OEt2 via in situ derived thioester enolates, which is followed by oxidative elimination to give alpha-alkenyl-beta'-hydroxy thioesters. Overall, the procedure is rapid, efficient, and generally applicable, even to beta-substituted acryloyl chlorides, thus providing an alternative to the Morita-Baylis-Hillman reaction with substantially greater synthetic scope and utility.
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