Objective: To analyze the clinical manifestations and imaging features of hemophilic pseudotumor.

Methods: Eight patients with hemophilic pseudotumor, all males, aged 26.1 (18 -38), were hospitalized, underwent resection of pseudotumor and bone reconstruction, and followed up for 38.6 months (7 months to 11 years). The clinical data were analyzed.

Results: Femur was involved in 4 patient, and fifth metacarpus, iliopsoas, quadriceps femoris, and gastrocnemius were involved in 1 patient respectively. No recurrence was found. Excellent healing was seen in 6 cases, claudication occurred in 1 case with shortening femur, while unpleasant outcome happened to 1 case because of formation of clotting factor inhibitor, together with poor wound-healing waiting for amputation.

Conclusion: Medical history and imaging features are essential for the diagnosis of hemophilic pseudotumor. It is the key for successful treatment to master its clinical characteristics.

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