This paper details the copper-catalyzed ring expansion of vinyl aziridines to 3-pyrrolines. Broad substrate scope (24 examples) using tosyl- and phthalimide-protected vinyl aziridine substrates is observed. Cu(hfacac)2 was determined to be superior to all other catalysts tested.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646081 | PMC |
| http://dx.doi.org/10.1021/ol802123e | DOI Listing |
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