The aim of this study was to compare the efficacy of an ionic and a conventional toothbrush in reducing gingival inflammation measured by gingival crevicular fluid (GCF) volume. Twenty dental students participated in this randomized crossover clinical trial. Quigley-Hein (QH) Plaque Index was assessed in six sites per tooth. GCF was measured in 3 teeth. Two experimental periods of 28 days with a 14-day washout were set. Mean values of GCF were calculated and tested by paired sample t-test. Correlations between % QH = O and alterations in GCF were performed. No significant differences were observed between conventional and ionic toothbrushes respectively neither at baseline (.62 +/- .19 vs. .55 +/- .18) nor at 28 days (.44 +/- .12 vs. .47). A negative correlation (-.33) was detected between the increase in % of QH = O and GCF for both brushes. It may be concluded that the performance of an ionic toothbrush does not differ from that of a conventional brush.
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J Chromatogr Sci
January 2025
Department of Chemistry, Ilam Branch, Islamic Azad University, Daneshjoo Blvd., Ilam 6931133145, Iran.
In the present study, metal-organic frameworks, MIL-101(Fe) and MIL-53(Al), were synthesized under solvothermal conditions and were characterized by Fourier transform infrared spectroscopy, X-ray energy diffraction spectroscopy and scanning electron microscopy. The synthesized metal-organic frameworks were utilized for the purpose of dispersive micro-solid phase extraction of sorafenib in both human plasma and wastewater, which was subsequently followed by high performance liquid chromatography with ultraviolet determination. Parameters affecting extraction efficacy including adsorbent amount, ionic strength, pH, type of elution solvent, adsorption and desorption time were optimized.
View Article and Find Full Text PDFRSC Adv
January 2025
Norwegian Tribology Center, Department of Mechanical and Industrial Engineering, Norwegian University of Science and Technology (NTNU) Trondheim Norway
The focus on energy efficiency to move towards a more sustainable use of resources has intensified efforts to minimize friction and wear in mechanical systems, which account for 23% of the world's energy consumption. In this study, polyoxometalate ionic liquids (POM-ILs) are introduced as environmentally acceptable lubricant additives, for their potential friction-reducing and anti-wear (AW) properties. These compounds, characterized by their complex structures and tunable properties, have been investigated for their tribological performance across base fluids of varying polarities.
View Article and Find Full Text PDFEur J Med Chem
January 2025
Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address:
Intravenously administered nanoparticles (NPs) often bind with plasma proteins, forming the protein corona that promotes rapid systemic clearance, a primary challenge in nanomedicine. In this study, we developed a pH- and GSH-sensitive "stealth" nanodelivery system, PTX@NPs-aPD1-IL, for sequential drug release. By using a biocompatible choline-based ionic liquid (IL) as the coating for NPs, the interaction and adsorption of NPs with serum proteins were reduced, achieving targeted delivery to the lung organ and increasing drug accumulation.
View Article and Find Full Text PDFEnviron Technol
January 2025
Department of Civil Engineering, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
The remediation of oil-contaminated soil poses significant environmental challenges, often necessitating innovative approaches for effective and sustainable solutions. This study focuses on the synthesis, characterisation, and application of biodegradable capsules loaded with surfactant for enhanced oil remediation of a clean sand. By controlling the release properties of capsules, the research aims to overcome the limitations of conventional surfactant-based remediation methods, such as rapid washout and reduced efficacy over time.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3E3, Canada.
Restenosis remains a long-standing limitation to effectively maintain functional blood flow after percutaneous transluminal angioplasty (PTA). While the use of drug-coated balloons (DCBs) containing antiproliferative drugs has improved patient outcomes, limited tissue transfer and poor therapeutic targeting capabilities contribute to off-target cytotoxicity, precluding adequate endothelial repair. In this work, a DCB system was designed and tested to achieve defined arterial delivery of an antirestenosis therapeutic candidate, cadherin-2 (N-cadherin) mimetic peptides (NCad), shown to selectively inhibit smooth muscle cell migration and limit intimal thickening in early animal PTA models.
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