AI Article Synopsis
- Alzheimer's disease patients often experience behavioral and psychological symptoms of dementia (BPSD), and genetic factors may influence these symptoms, with a focus on the dopamine transporter (DAT1) gene in this study.
- The study analyzed data from 395 Alzheimer's patients to explore the relationship between their symptoms and the DAT1 gene's variable number tandem repeat (VNTR) polymorphism.
- Results showed a potential link between specific gene alleles and symptoms like irritability and aberrant motor behavior, though these findings need further validation in larger groups.
Article Abstract
Background/aims: Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investigation of the dopamine transporter (DAT1) gene in BPSD.
Methods: Our large cohort of 395 patients with probable Alzheimer's disease was dichotomised into whether they had ever suffered from a given symptom over the study period or not, based on longitudinal data using the BPSD (Neuropsychiatric Inventory). These measures were related to the DAT1 3'-untranslated region (UTR) variable number tandem repeat (VNTR) polymorphism.
Results: Potential associations were revealed between the 9-repeat allele and presence of irritability and between the 10-repeat allele and aberrant motor behaviour (AMB); however, these do not remain significant after correction for multiple testing. No associations were observed with delusions, hallucinations, depression, agitation/aggression or elation.
Conclusion: Our data suggest that the DAT1 3'-UTR VNTR could play a role in susceptibility to irritability and AMB. The findings presented here require replication in large well-characterised cohorts.
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| http://dx.doi.org/10.1159/000160958 | DOI Listing |
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