Objective: To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement.
Design: Prospective, randomised, double blind placebo controlled trial.
Setting: Winford Orthopaedic Hospital, Bristol.
Subjects: 148 patients having primary total hip replacement.
Intervention: Warfarin 1 mg given daily for one week before and three weeks after surgery.
Main Outcome Measure: Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method.
Results: Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%).
Conclusion: Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1670497 | PMC |
| http://dx.doi.org/10.1136/bmj.303.6796.219 | DOI Listing |
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