Objective: To observe the effects of scavenger receptor class A type I/II on lipid metabolism in mice.
Methods: TG, TC, HDL-C, LDL-C, and ApoB levels, were measured by enzymatic determination. Lipid accumulation in mice liver was analyzed by the lipid-specific Oil Red O-positive staining of frozen liver sections.
Results: The levels of serum TG, TC, LDL-C and ApoB of SR-A I/II knockout mice were more higher than those of wild type mice (P < 0.01). The histological analyses revealed hepatocytes SR-A I/II deficient mice were distended and massive lipids SR-A I/II deficient mice accumulated in liver, and both SR-A I/II deficient mice were more severer than those of the wild type mice.
Conclusion: Scavenger receptor class A type I/II could play an important role in regulation of lipid metabolism in mice.
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