Uni-Elbow arthroplasty is an innovative alternative to radial head resection or implant removal in addressing painful radiocapitellar joint arthrosis. As an "arthroplasty" solution, it retains the biomechanical function of the elbow and obviates the potential complications of not having a radial head. Although its role is likely to evolve as clinical experience accumulates and reported outcomes increase in number, it may have a role in the setting of acute and chronic Essex-Lopresti lesions, and when previous radial head arthroplasty has resulted in capitellar arthrosis but when removal of the implant alone is felt to be contraindicated.
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Am J Physiol Heart Circ Physiol
January 2025
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Increased blood pressure upon standing is considered a cardiovascular risk factor. We investigated the reproducibility of changes in aortic blood pressure, heart rate, stroke volume, cardiac output, and systemic vascular resistance during three passive head-up tilts (HUT) in 223 participants without cardiovascular medications (mean age 46 years, BMI 28 kg/m2, 54% male). Median time gap between the first and the second HUT was 9 weeks and the second and the third HUT 4 weeks.
View Article and Find Full Text PDFCase: We present a 79-year-old woman with a complex elbow fracture including a comminuted proximal ulna fracture, coronoid process fracture, and comminuted radial head fracture treated with primary total elbow arthroplasty (TEA). The patient completed an early therapy protocol and had complete healing. At 15 months postoperatively, she had full pronosupination and elbow arc of motion from 10 to 135° with no reported pain.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA
Background: In the context of pathological aging and Alzheimer's disease (AD), the overexpression of calcineurin has been identified as a factor linked to astrocyte reactivity, neuronal death, and inflammation. This suggests that inhibiting calcineurin or downstream nuclear factor of activated T cells (NFAT) signaling could be a promising strategy for preventing or slowing down AD pathophysiology.
Method: Baseline and annual MRI sessions including higher‐order diffusion‐weighted imaging was performed over four years on 43 dogs ranging from 5 to 8.
Alzheimers Dement
December 2024
University of Florida, Gainesville, FL, USA
Background: Repetitive mild traumatic brain injury (rmTBI) represents a substantial health challenge, urging a more thorough investigation into its early effects and possible interventions. The collective consequences of rmTBI encompass various neurobiological and neuropsychological impairments, increasing susceptibility to diseases like Alzheimer's and related dementias. Employing the Closed‐Head Impact Model of Engineered Rotational Acceleration (CHIMERA) approach for TBI induction, our prior study revealed connectivity alterations within 53% of regions in young and aged wild‐type mice five days post‐injury.
View Article and Find Full Text PDFJ Pediatr Orthop B
January 2025
Trauma Research Center, Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Hereditary multiple exostoses is an autosomal dominant genetic condition primarily affecting long bones. Forearm deformities, including wrist ulnar deviation, ulnar shortening, radial or ulnar bowing, and radial head dislocation, are common manifestations. Gradual ulnar lengthening is suggested as a viable treatment option for managing these deformities.
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