Objectives: Previous research has demonstrated that alpha2 agonists improve working memory performances in healthy individuals and in primates with prefrontal lesions. We conducted this study to determine whether the alpha2 agonist, guanfacine, could improve working memory performances in patients with frontal lobe epilepsy (FLE) and/or in those with focal epilepsy outside the frontal lobes (ie, temporal lobe epilepsy [TLE]).
Methods: Fourteen patients with FLE, 13 patients with TLE, and 10 healthy controls completed immediate and delayed match-to-sample tasks before and after ingestion of 2 to 3 mg of guanfacine.
Results: All 3 groups showed an increase in accuracy on the delayed match-to-sample task, but not the immediate match-to-sample task, following administration of guanfacine. Inspection of the group means revealed somewhat greater benefits for the control and FLE groups relative to the TLE group. Increased accuracy was not associated with slower performances in any group, suggesting that the cognitive benefits of guanfacine did not occur at the expense of increased sedation.
Conclusions: These data suggest that guanfacine improves working memory in patients with FLE and may be a viable treatment for attenuating such deficits in this patient population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/WNF.0b013e3181633461 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterizing executive functioning and associated behaviors in individuals with dual-specificity tyrosine phosphorylation-regulated kinase 1A () syndrome.
Front Neurosci
January 2025
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, United States.
Introduction: , a protein kinase located on human chromosome 21, plays a role in postembryonic neuronal development and degeneration. Alterations to have been consistently associated with cognitive functioning and neurodevelopmental disorders (e.g.
View Article and Find Full Text PDFEffects of Difficulties in Executive Functions on Behavioral and Adaptive Problems in Italian Autistic Preschoolers.
Clin Neuropsychiatry
December 2024
IRCCS Stella Maris Foundation, Pisa, Italy.
Objective: To describe the relationship between executive functions (EF) and symptom's severity, behavioral problems, and adaptive functioning in autistic preschoolers.
Method: Seventy-six autistic preschoolers (age-range: 37-72 months; SD: 8.67 months) without intellectual disability were assessed.
Characteristics of Sluggish Cognitive Tempo among adults with ADHD: objective neurocognitive measures align with self-report of executive function.
Front Child Adolesc Psychiatry
July 2023
Department of Psychiatry, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, United States.
Introduction: Sluggish Cognitive Tempo (SCT) is a syndrome characterized by cognitive hypo-arousal that often appears as daytime sleepiness or drowsiness, mental fogginess, being easily confused, having difficulty with holding and manipulating information in working memory, and being forgetful. Although it frequently co-travels with attention-deficit/hyperactivity disorder (ADHD) or other conditions and confers significantly greater impairment, there are few studies examining SCT among adults with ADHD. Understanding what features SCT confers in association with ADHD, distinct from other conditions associating with ADHD, is critically important to confirm if SCT is a distinct syndrome that requires special assessment methods and special, distinct treatment efforts to reduce its impact.
View Article and Find Full Text PDF[Prediction of areas of snail spread in Anhui Province based on five machine learning models].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
December 2024
Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui 230601, China.
Objective: To predict the areas of snail spread in Anhui Province from 1977 to 2023 using machine learning models, and to compare the effectiveness of different machine learning models for prediction of areas of snail spread, so as to provide insights into investigating the trends in areas of snail spread.
Methods: Data pertaining to snail spread in Anhui Province from 1977 to 2023 were collected and a database was created. Five machine learning models were created using the software Matlab R2019b, including support vector regression (SVR), nonlinear autoregressive (NAR) neural network, back propagation (BP) neural network, gated recurrent unit (GRU) neural network and long short-term memory (LSTM) neural network models, and the model fitting effect was evaluated with mean absolute error (MAE), root mean squared error (RMSE) and coefficient of determination ().
Short-term variability of Alzheimer's disease plasma biomarkers in a mixed memory clinic cohort.
Alzheimers Res Ther
January 2025
Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmans Vej 8, Copenhagen, DK-2100, Denmark.
Background: For clinical implementation of Alzheimer's disease (AD) blood-based biomarkers (BBMs), knowledge of short-term variability, is crucial to ensure safe and correct biomarker interpretation, i.e., to capture changes or treatment effects that lie beyond that of expected short-term variability and considered clinically relevant.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!