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Application value of central venous-arterial carbon dioxide partial pressure difference in postoperative cognitive dysfunction in patients with acute aortic dissection.
J Cardiothorac Surg
January 2025
Department of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Objective: This study aims to investigate the clinical application value of the central venous-arterial carbon dioxide partial pressure difference (Pv-aCO2) in postoperative cognitive dysfunction(POCD) in patients with acute aortic dissection.
Methods: A retrospective analysis was conducted on the general data of 236 patients. Blood gas samples were collected from the arterial and venous lines at various time points during the surgery, including before and after the initiation of cardiopulmonary bypass (CPB), immediately after CPB initiation, before and after deep hypothermic circulatory arrest, 30 min after rewarming, and 5 min before weaning from CPB.
The role of microglia in Neuroinflammation associated with cardiopulmonary bypass.
Front Cell Neurosci
December 2024
Department of Trauma Center, The First Affiliated Hospital of China Medical University, Shenyang, China.
Article Synopsis
- Cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) are crucial techniques in cardiac surgery that can lead to neuroinflammation through microglia activation in the central nervous system.
- Research typically focuses on conditions like Alzheimer's and Parkinson's but pays less attention to how these processes occur during cardiac surgery.
- This review highlights the need to explore microglia’s role in neuroinflammation related to CPB and DHCA, aiming to improve patient outcomes and guide future treatment strategies for cardiac surgery patients.
Application of high-quality targeted temperature management guided by multimodal brain monitoring in brain protection of patients with cardiac arrest: A case series.
Medicine (Baltimore)
December 2024
Department of Intensive Care Medicine, Xiangya Hospital, Central South University, Changsha, China.
Rationale: Cardiac arrest (CA) is an acute emergency with high mortality and is closely associated with the risk of brain damage or systemic ischemia-reperfusion injury, post-traumatic stress symptoms.
Patient Concerns: Targeted temperature management in the intensive care unit can improve the neurological outcomes of patients who are comatose after resuscitation from CA. However, there is often a lack of specific evaluation methods for optimal target temperature settings.
Safety of prolonged bilateral antegrade cerebral perfusion in aortic arch surgery with moderate hypothermia.
Eur J Cardiothorac Surg
December 2024
Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY, USA.
Objectives: This study investigates the impact of bilateral antegrade cerebral perfusion (ACP) time on outcomes in aortic arch surgery.
Methods: In total, 961 patients underwent either hemiarch (n = 385) or total arch replacement (n = 576) with bilateral ACP and moderate hypothermia management between 2006 and 2020 across 2 aortic centres. ACP time was categorized into 4 groups (≤30 min: n = 169, 30-60 min: n = 298, 60-90 min: n = 261, >90 min: n = 233).
Shelters in Alpine Rescue: Can They Create a Comfortable Zone at the Deployment Site?
Wilderness Environ Med
December 2024
Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Article Synopsis
- Lightweight polyester shelters are commonly used in mountain rescue, but little is known about the stress experienced by rescuers while using them.
- A study with 48 seasoned rescuers assessed both objective (temperature, humidity, gas concentrations) and subjective stress factors (comfort, noise, air quality) during CPR training in these shelters.
- The findings indicate that the shelters significantly improved physical comfort and most rescuers reported positive working conditions despite rising temperatures and carbon dioxide levels during the process.
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