Background: Tumor necrosis factor-alpha (TNF-alpha), C-telopeptide pyridinoline cross-links of type I collagen (ICTP), and receptor activator of nuclear factor-kappa B ligand (RANKL) have been associated with bone remodeling and periodontal tissue destruction. This study evaluated the level of these biomarkers in saliva with respect to periodontal disease status.
Methods: Levels of TNF-alpha in unstimulated whole saliva of 74 adults (35 subjects with moderate to severe periodontal disease and 39 healthy controls) and salivary levels of RANKL and ICTP of a subset of 21 subjects and 21 matched controls were examined using enzyme immunosorbent assays in a case-control clinical study.
Results: Salivary levels of TNF-alpha were detected in all subjects, whereas levels of ICTP and RANKL were detected in only a minority of subjects. Mean salivary levels of TNF-alpha were significantly higher in individuals with periodontal disease (mean: 4.33 pg/ml) than in controls (mean: 2.03 pg/ml; P = 0.02), with a maximum level (27.96 pg/ml) observed in periodontitis. Subjects with salivary TNF-alpha levels above a threshold of 5.75 pg/ml (i.e., two standard deviations above the mean of the controls) had significantly more sites with bleeding on probing, probing depths >/=4 mm, and attachment loss > or =2 mm (P < or =0.01).
Conclusion: Salivary levels of TNF-alpha were elevated in patients who had clinical indicators of periodontitis, suggesting that this biomarker may serve in a panel of salivary biomarkers that could facilitate the screening, diagnosis, and management of periodontal disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1902/jop.2008.080070 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral health and rheumatoid arthritis: a case control study.
Cent Eur J Public Health
December 2024
Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic.
Objectives: Patients suffering from rheumatoid arthritis (RA) are repeatedly affected by oral diseases or problems, including dental caries and periodontal diseases (PDs). Periodontitis and rheumatoid arthritis are chronic inflammatory destructive diseases that share many similarities. The objective of this study was to assess oral health status including examination of hard dental tissues and periodontium in patients with rheumatoid arthritis and compare the results with healthy controls.
View Article and Find Full Text PDFClinical and radiographic outcomes of extra-short implants (≤ 6 mm) in the posterior atrophic jaws: a retrospective cohort study.
Int J Implant Dent
January 2025
Department of Neurosciences, School of Dentistry, University of Padua, Padua, Italy.
Objective: This study aimed at investigating implant survival rate and marginal bone loss (MBL) around extra-short implants. The impact of the loading protocol and of the use of an intermediate abutment was also evaluated, to explore possible differences in terms of the outcome measures.
Materials And Methods: Patients with single or multiple mandibular or maxillary posterior edentulism rehabilitated using extra-short 5-6 mm long implants were included.
[Prevention of periodontal inflammation in microgravity modeling].
Stomatologiia (Mosk)
January 2025
A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
The Purpose: Of the study was to assess oral microbiocenosis changes in participants of microgravity modeling in a control group and using prophylaxis in the form of a probiotic supplement with 1.0·10 CFU of strain in one lozenge and a dairy product containing not less than 1·10 CFU of s strain in one gram.
Materials And Methods: The study included 15 participants aged 25-40 years from the "Dry Immersion-2018" experiment.
The Aim Of The Study: To study the expression of NOD receptors of immunotropic periodontal tissue cells in patients with aggressive periodontitis before and after complex treatment.
Materials And Methods: 15 patients aged 22 to 36 years with aggressive periodontitis were examined before and 21 days after the start of complex treatment. 15 patients with fibroids of the oral mucosa without signs of inflammation served as controls.
Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions.
World J Psychiatry
January 2025
Mental Health Education and Counseling Center, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China.
This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing (MI) in addressing anxiety and depression among young and middle-aged patients following percutaneous coronary intervention. It further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease management. MI aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhancing intrinsic motivation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!